Document Detail

Endovascular treatment of near-fatal neonatal superior vena cava syndrome.
MedLine Citation:
PMID:  21116206     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We describe the endovascular management of an 8-wk-old previously healthy female who developed superior vena cava syndrome secondary to Pseudomonas septic shock and disseminated intravascular coagulation. Doppler ultrasound confirmed near-total thrombotic occlusion of the superior vena cava and right internal jugular vein. She was taken emergently for cardiac catheterization, which confirmed the large superior vena cava thrombus extending into the right internal jugular vein and innominate vein with almost complete occlusion of the innominate vein. The superior vena cava to right atrium gradient was 14 mm Hg with very little antegrade flow into the right atrium, right femoral artery occlusion, and branch pulmonary artery emboli. Intervention involved serial balloon dilation inflations across the superior vena cava and innominate vein with improvement in the superior vena cava to right atrium gradient to 5 mm Hg and significant improvement in left ventricular function. Anticoagulation included heparin infusion for 48 hrs followed by enoxaparin for 1 month, alteplase for 48 hrs, eptifibatide (glycoprotein IIb/IIIa inhibitor) for 9 days followed by aspirin.
DATA SOURCES: Chart review. Case reports are exempt from approval of our Institutional Review Board.
CONCLUSIONS: Daily head ultrasounds were performed without evidence of intracranial hemorrhage. All thromboses resolved within 3 wks. Her organ function recovered and she was discharged to home. The etiology of her colitis is still unknown. At 9-month follow-up, she was doing well with no residual organ dysfunction.
Elizabeth H Mack; Derek S Wheeler; Russel Hirsch
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  12     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-09     Completed Date:  2012-05-10     Revised Date:  2013-08-23    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e410-2     Citation Subset:  IM    
Division of Pediatric Critical Care , Palmetto Health Children's Hospital, University of South Carolina School of Medicine, Columbia, SC, USA.
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MeSH Terms
Anticoagulants / therapeutic use
Pseudomonas / isolation & purification
Pseudomonas Infections / complications
Superior Vena Cava Syndrome / etiology,  surgery*
Thrombosis / physiopathology*,  surgery
Vascular Surgical Procedures / methods*
Grant Support
Reg. No./Substance:

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