Document Detail


Endovascular treatment of intracranial aneurysms with matrix detachable coils: midterm anatomic follow-up from a prospective multicenter registry.
MedLine Citation:
PMID:  17921229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Polyglycolic/polylactic acid-covered platinum coils have been proposed to reduce the rate of aneurysm recanalization after endovascular treatment. A prospective and multicenter registry was conducted in France to evaluate the safety and short-term and midterm efficacy of Matrix coils. This analysis focused on anatomic midterm results. MATERIALS AND METHODS: Two hundred thirty-six patients harboring 244 ruptured or unruptured aneurysms treated via endovascular approach by using Matrix coils were included in this registry. Treatment was totally or partially performed by using Matrix coils. Anatomic results were evaluated on postoperative and last-follow-up digital subtraction angiography (DSA) by using the Raymond scale. "Recanalization" was defined as worsening, and "progressive thrombosis" was defined as improvement on the Raymond scale. RESULTS: Anatomic midterm follow-up was obtained in 165 of 236 patients (70%) harboring 171 aneurysms (range, 6-27 months; mean, 14 +/- 4 months). At midterm follow-up angiography, 79 aneurysms were completely occluded (46.2%), 43 had a neck remnant (25.1%), and 49 had an aneurysm remnant (28.7%). Of 171 aneurysms, recanalization was observed in 44 patients (25.7%), including major recanalization in 18 patients (10.5%). Recanalization was more frequent if the embolized volume of aneurysm was </=25%. Progressive thrombosis was observed in 52 aneurysms (30%). No bleeding or rebleeding was observed during the period of follow-up. CONCLUSION: The efficacy of Matrix coils in preventing recanalization was not demonstrated in our series. In agreement with previous studies using bare platinum coils, volumic occlusion was an important feature for the prediction of aneurysm recanalization. A high percentage of progressive thrombosis in incompletely treated aneurysms was observed in our series, suggesting a biologic activity of Matrix coils.
Authors:
L Pierot; X Leclerc; A Bonafé; S Bracard;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2007-10-05
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  29     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Affiliation:
Department of Neuroradiology, Reims University, Reims, France. lpierot@chu-reims.fr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Embolization, Therapeutic / instrumentation*,  statistics & numerical data*
Female
France / epidemiology
Humans
Intracranial Aneurysm / epidemiology*,  radiography,  therapy*
Male
Middle Aged
Registries*
Risk Assessment / methods*
Risk Factors
Treatment Outcome
Investigator
Investigator/Affiliation:
Anne Pasco / ; Xavier Barreau / ; Jérôme Berge / ; Patrick Courthéoux / ; Emmanuel Chabert / ; Jean Gabrillargues / ; Xavier Leclerc / ; Francis Turjman / ; Alain Bonafé / ; Serge Bracard / ; Jacques Desal / ; Alessandra Biondi / ; Nader Sourour / ; Emmanuel Houdart / ; Jacques Drouineau / ; Laurent Pierot / ; Christophe Cognard / ; Denis Herbreteau /
Comments/Corrections
Comment In:
AJNR Am J Neuroradiol. 2008 Jan;29(1):62   [PMID:  17925368 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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