Document Detail


Endovascular treatment of intracranial aneurysms using Matrix coils: short- and mid-term results in ruptured and unruptured aneurysms.
MedLine Citation:
PMID:  19005374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: A prospective multicenter registry was conducted in France to evaluate the safety and efficacy of Matrix coils (Boston Scientific Neurovascular, Fremont, CA). The short- and mid-term results are presented. METHODS: From January to October 2004, 236 patients harboring ruptured (Group I) or unruptured (Group II) aneurysms were treated via an endovascular approach with Matrix coils and were included in this registry. In-hospital morbidity and mortality was determined. One-year clinical follow-up data were obtained in 218 patients (92.4%). One-year angiographic follow-up data were obtained in 165 patients (171 aneurysms, 70.1%). RESULTS: In Group I, in-hospital morbidity and mortality rates were 5.8 and 6.5%, respectively, with a procedure-related morbidity and mortality of 3.6 and 1.4%, respectively. At 1 year, the morbidity and mortality rates were 2.4 and 11.0%, respectively. In Group II, procedure-related morbidity and mortality rates were 1.0 and 0.0%, respectively. At 1 year, the morbidity and mortality rates were 1.1 and 0%, respectively. For both groups, no bleeding or rebleeding was observed during the follow-up period. The only factor associated with an increased rate of complications was delay before treatment of more than 2 days after bleeding. Aneurysm recanalization was observed in 44 aneurysms (25.7%). CONCLUSION: In-hospital and 1-year morbidity and mortality rates in patients harboring ruptured or unruptured aneurysms treated with Matrix coils were similar to those previously reported with the use of bare coils. The efficacy of Matrix coils to prevent aneurysm recanalization was not demonstrated, despite a high percentage of progressive thrombosis that suggests biological activity resulting from Matrix coils.
Authors:
Laurent Pierot; Xavier Leclerc; Alain Bonafé; Serge Bracard;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurosurgery     Volume:  63     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-13     Completed Date:  2008-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  850-7; discussion 857-8     Citation Subset:  IM    
Affiliation:
Department of Neuroradiology, University of Reims, Reims, France. lpierot@chu-reims.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aneurysm, Ruptured / therapy*
Embolization, Therapeutic / adverse effects,  instrumentation*,  mortality
Follow-Up Studies
France
Hospital Mortality
Humans
Intracranial Aneurysm / therapy*
Middle Aged
Neurosurgical Procedures / adverse effects,  instrumentation*,  mortality
Postoperative Complications / etiology
Prospective Studies
Prostheses and Implants* / adverse effects
Registries / statistics & numerical data
Stents
Treatment Outcome
Vascular Surgical Procedures / adverse effects,  instrumentation*,  mortality
Young Adult
Investigator
Investigator/Affiliation:
Anne Pasco / ; Xavier Barreau / ; Jérôme Berge / ; Patrick Courthéoux / ; Emmanuel Chabert / ; Jean Gabrillargues / ; Xavier Leclerc / ; Francis Turjman / ; Alain Bonafé / ; Serge Bracard / ; Hubert Desal / ; Mustapha Dib / ; Jacques Sedat / ; Alessandra Biondi / ; Nader Sourour / ; Emmanuel Houdart / ; Jacques Drouineau / ; Laurent Pierot / ; Christophe Cognard / ; Denis Herbreteau /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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