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Endovascular treatment of infectious intracranial aneurysms.
MedLine Citation:
PMID:  22892702     Owner:  NLM     Status:  Publisher    
Infectious intracranial aneurysms (IIA) are rare but a considerable source of morbidity and mortality as a result of rupture. Most patients with these lesions have considerable medical comorbidities, making endovascular approaches a crucial modality in their treatment armamentarium. Contributing our own case, we performed a comprehensive review of the literature to illustrate overall results and outcomes for patients with IIA treated with endovascular approaches. Incorporating our own case, we found 65 patients harboring 72 IIA across 31 reports. Fifty-one were treated via parent artery occlusion (71 %), 17 via direct aneurysm embolization (24 %), two via stent-coiling (3 %), and two with stent monotherapy (3 %). Twenty-nine IIAs were treated with n-butylcyanoacrylate (NBCA) (40 %), 25 with coils (35 %), seven with Onyx or ethylene vinyl alcohol (10 %), five with detachable balloons (7 %), four with stents (6 %), and one with autologous clot (1 %). One case of incomplete aneurysm occlusion and two cases of recanalization were reported. Six symptomatic periprocedural ischemic events were reported (9 %), with only three resulting in permanent sequelae (5 %). No infectious complications were reported. Incorporating the natural history of the disease, 28 patients were neurologically intact (43 %), while seven had died at the time of follow-up (11 %). Endovascular treatment of ruptured, symptomatic, or enlarging IIA is an excellent treatment modality with high occlusion rates and low procedure-related complication rates. Distal IIA are more often treated with parent artery occlusion, in our hands, preferentially with Onyx, while proximal lesions may be treated with direct stent-coiling or even flow-diverting stent monotherapy.
Bradley A Gross; Ajit S Puri
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-15
Journal Detail:
Title:  Neurosurgical review     Volume:  -     ISSN:  1437-2320     ISO Abbreviation:  Neurosurg Rev     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7908181     Medline TA:  Neurosurg Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Neurological Surgery, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA,
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