Document Detail

Endovascular treatment of brain arteriovenous malformations using onyx: results of a prospective, multicenter study.
MedLine Citation:
PMID:  19223075     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: To evaluate the safety and efficacy of onyx for embolization of brain arteriovenous malformations (BAVM). METHODS: A prospective, multicenter study was conducted in France to evaluate embolization of BAVM with onyx. From May 2003 to March 2005, 50 patients (26 females, 24 males; mean age: 34.8 years, range: 16-64years) were included. Clinical presentation was haemorrhage in 22 patients (44.0%), seizures in 16 patients (32.0%), headaches in six patients (12.0%) and progressive neurological deficit in two cases (4.0%). Four patients were asymptomatic (8.0%). RESULTS: One hundred and forty-ninesessions of embolization were performed: one to eight sessions/patient with a mean of 3.0sessions. One hundred and sixteen sessions (77.9%) were performed with onyx, 20 sessions (13.4%) with glue and 13 sessions (8.7%) with onyx and glue. Symptomatic acute postembolization haemorrhage (APEH) was observed in four cases (8.0% per patient). At 1 month, morbidity and mortality related to the treatment were of 8% and 2%, respectively. Complete BAVM occlusion was obtained in 8.3% of cases. In the remaining cases, occlusion rate was between 99 and 80% in 56.3% of patients, 79 and 60% in 16.7%, and less than 60 in 18.7%. In case of incomplete occlusion, complementary treatment was performed by radiosurgery. CONCLUSION: Onyx is suitable for BAVM embolization with acceptable morbidity and mortality.
L Pierot; A-C Januel; D Herbreteau; X Barreau; J Drouineau; J Berge; N Sourour; C Cognard
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-02-14
Journal Detail:
Title:  Journal of neuroradiology. Journal de neuroradiologie     Volume:  36     ISSN:  0150-9861     ISO Abbreviation:  J Neuroradiol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705086     Medline TA:  J Neuroradiol     Country:  France    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Department of Radiology, hôpital Maison-Blanche, 45, rue Cognacq-Jay, 51092 Reims cedex, France.
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MeSH Terms
Dimethyl Sulfoxide / therapeutic use*
Embolization, Therapeutic*
Follow-Up Studies
Intracranial Arteriovenous Malformations / therapy*
Middle Aged
Polyvinyls / therapeutic use*
Prospective Studies
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Onyx copolymer; 0/Polyvinyls; 67-68-5/Dimethyl Sulfoxide

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