Document Detail


Endovascular reperfusion therapy in acute ischaemic stroke.
MedLine Citation:
PMID:  17419824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Endovascular reperfusion therapy in acute ischaemic stroke comprises a number of pharmacological and mechanical procedures. Mechanical embolectomy offers the promise of efficacious treatment for patients in whom pharmacological thrombolysis is contraindicated or might be ineffective. The purpose of this review is to outline endovascular reperfusion therapy in acute ischaemic stroke with focus on mechanical embolectomy.
MATERIALS & METHODS: Data on endovascular reperfusion therapy were acquired through searches in MEDLINE 1990-2006 by cross referencing relevant key words.
RESULTS: Mechanical embolectomy works well on large-volume proximal occlusions for which there was previously no effective treatment. Early safety trials are promising, efficacy in terms of recanalisation is substantial, and both safety and efficacy is expected to improve with further advances in technology.
CONCLUSIONS: Intravenous thrombolysis with tPA revolutionised acute stroke treatment a decade ago. Endovascular reperfusion therapy now offers the promise of a second revolution, expanding the number of patients eligible and the time window open for specific stroke treatment.
Authors:
L Thomassen; S J Bakke
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta neurologica Scandinavica. Supplementum     Volume:  187     ISSN:  0065-1427     ISO Abbreviation:  Acta Neurol. Scand., Suppl.c     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-10     Completed Date:  2007-07-06     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  0370337     Medline TA:  Acta Neurol Scand Suppl     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  22-9     Citation Subset:  IM    
Affiliation:
Department of Neurology, Haukeland University Hospital, University of Bergen, Bergen, Norway. ltho@haukeland.no
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MeSH Terms
Descriptor/Qualifier:
Acute Disease / therapy
Brain Ischemia / physiopathology,  surgery*
Cerebral Arteries / pathology,  radiography,  surgery*
Embolectomy / instrumentation*,  methods*,  standards
Humans
Intracranial Embolism / physiopathology,  surgery*
Intraoperative Complications / etiology,  prevention & control
Monitoring, Physiologic / standards
Stroke / physiopathology,  surgery*
Tissue Plasminogen Activator / adverse effects,  standards
Treatment Outcome
Chemical
Reg. No./Substance:
EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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