Document Detail

Endovascular management of acute symptomatic intracranial arterial occlusion.
MedLine Citation:
PMID:  17053609     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Acute ischemic stroke has reached epidemic proportions in the United States, affecting approximately 700,000 people annually. With the recent technological advancements in endovascular devices, clinicians now have tools capable of recanalizing acute intracranial occlusions. The combination of pharmacological thrombolysis and mechanical clot perturbation may result in increased rates of angiographic recanalization, which may lead to improvement in patient outcomes after acute stroke. METHODS: In this article, the various intra-arterial pharmacological and mechanical therapies used by interventionists to treat acute stroke are described. Strategies for using combinations of these therapies are discussed, as are preliminary radiographic and clinical outcomes. Techniques for complex mechanical stroke interventions are discussed in detail. RESULTS: Several advances in endovascular stroke technologies are becoming increasingly available. CONCLUSION: With proper patient selection, these therapies may lead to increased recanalization rates and better patient outcomes.
Erol Veznedaroglu; Elad I Levy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurosurgery     Volume:  59     ISSN:  1524-4040     ISO Abbreviation:  Neurosurgery     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-20     Completed Date:  2007-04-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S242-50; discussion S3-13     Citation Subset:  IM    
Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
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MeSH Terms
Acute Disease
Blood Vessel Prosthesis*
Brain Ischemia / therapy*
Fibrinolytic Agents / administration & dosage*
Intracranial Arterial Diseases / therapy*
Physician's Practice Patterns
Practice Guidelines as Topic
Thrombolytic Therapy / methods*
Vascular Surgical Procedures / instrumentation,  methods*
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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