| Endovascular irradiation prevents smooth muscle cell proliferation and neointimal hyperplasia in rabbits. | |
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MedLine Citation:
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PMID: 12840905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study examined the temporal responses and the efficacy of 192Ir-HDR endovascular irradiation for preventing smooth muscle cell proliferation of rabbit iliac arteries after PTA with a cutting balloon catheter. Endovascular irradiation with 12 Gy was randomly performed on the one side of iliac arterial segment with the unirradiated side serving as a control. Animals were euthanatized 1, 2, 3, 4, 8 and 12 week(s) after angioplasty. Histopathological and immunohistochemical studies were carried out. Histopathology showed repair of the dissection by cellular accumulation and a striking reduction in the amount of neointimal hyperplasia in the irradiated arteries as compared with control vessels. A peak of PCNA-positive ratio was in neointima of the control arterial segments at a week. 2-4 weeks after irradiation, the neointimal PCNA-positive ratio was still significantly increased in the control arterial segments compared with the irradiated arterial segments. After 8 weeks, PCNA-positive ratio was below 1% in both irradiated arterial segments and the control. Our results showed that the 192Ir-HDR afterloading irradiation with a dose of 12 Gy can be considered sufficient for inhibiting neointimal hyperplasia in angioplastized rabbit iliac arteries with cutting balloon catheter. |
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Authors:
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L Xu; Y Wu; G Feng; M Oguchi; H Yokota; T Nakagawa; I Yamamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Tongji Medical University = Tong ji yi ke da xue xue bao Volume: 19 ISSN: 0257-716X ISO Abbreviation: J. Tongji Med. Univ. Publication Date: 1999 |
Date Detail:
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Created Date: 2003-07-04 Completed Date: 2003-10-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8605495 Medline TA: J Tongji Med Univ Country: China |
Other Details:
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Languages: eng Pagination: 240-5 Citation Subset: IM |
Affiliation:
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Department of Radiology, Xiehe Hospital, Tongji Medical University, Wuhan 430030. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Animals Cell Division / radiation effects Dose-Response Relationship, Radiation Hyperplasia / prevention & control Iliac Artery* / pathology, radiation effects Iridium Radioisotopes Muscle, Smooth, Vascular / pathology*, radiation effects* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Iridium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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