Document Detail


Endovascular embolization of the swine rete mirabile with Eudragit-E 100 polymer.
MedLine Citation:
PMID:  17569986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Both adhesive and nonabrasive embolic agents are available for arteriovenous malformation (AVM) embolization. The purpose of this study was to evaluate a novel ethanol-based nonadhesive liquid embolic material in a swine AVM model. MATERIALS AND METHODS: Eudragit (copolymer of methyl and butyl methacrylate and dimethylaminoethyl methacrylate) was dissolved in 50% ethanol and 50% iopamidol. Eudragit was injected into 9 retia mirabilia (RMs). Ethanol and iopamidol mixture were injected into 4 RMs for comparison. Three RMs embolized with Eudragit mixture were evaluated both angiographically and histopathologically acutely (3-24 hours) and at 30 days and 90 days after embolization. RESULTS: No procedural complications from Eudragrit embolization were noted, including retention or adhesion of the microcatheter. Various degrees of inflammation were observed in the acute and 30-day specimens. Two RMs showed partial recanalization on both histopathology and follow-up angiography in the 30-day group. Arterial fibrosis and calcification were observed in the 30- and 90-day specimens. The internal elastic lamina was disrupted in the 30- and 90-day specimens, but there was no evidence of Eudragit extravasation or hemorrhage. Endothelial damage was seen in all specimens and was particularly severe in the 30- and 90-day specimens. CONCLUSION: Eudragit polymer induced inflammation in thrombosis similar to n-butyl 2-cyanoacrylate, but without the disadvantages of perivascular hemorrhage and extravasation of embolization material. Although recanalization of some embolized RMs was noted, further investigation into Eudragit as a potentially useful embolic material for brain AVMs is warranted.
Authors:
H Arakawa; Y Murayama; C R Davis; D L Howard; W L Baumgardner; M P Marks; H M Do
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  28     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:    2007 Jun-Jul
Date Detail:
Created Date:  2007-06-15     Completed Date:  2007-08-08     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1191-6     Citation Subset:  IM    
Affiliation:
Department of Radiology, Stanford University Medical Center, Stanford, CA, USA. harakawa@jikei.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acrylates / administration & dosage*
Animals
Cranial Sinuses / drug effects*,  radiography*
Embolization, Therapeutic / methods*
Polymers / administration & dosage*
Swine
Treatment Outcome
Chemical
Reg. No./Substance:
0/Acrylates; 0/Eudragit E100; 0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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