Document Detail

Endovascular cryotherapy accentuates the accumulation of the fibrillar collagen types I and III after percutaneous transluminal angioplasty in pigs.
MedLine Citation:
PMID:  16445314     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the effect of endovascular cryotherapy (Cryo) on the density of collagen types I (CI) and III (CIII), which are involved in the dynamic modulation of extracellular matrix (ECM) after percutaneous transluminal angioplasty (PTA). METHODS: Twenty-one juvenile farm swine and 10 miniswine underwent PTA of the femoral arteries with and without Cryo (-50 degrees C for 2 minutes). Quantitative angiography, histomorphometry, and quantification of CI and CIII were performed at 1 week (n=7), 1 month (n=7), 3 months (n=7), and 6 months (n=10). RESULTS: PTA decreased the minimal luminal diameter (MLD) (range 3.48+/-0.18 to 4.2+/-0.39 mm) compared to baseline values (range 3.67+/-0.15 to 4.59+/-0.23 mm), but the application of Cryo maintained the MLDs at preprocedural levels (range 3.88+/-0.31 to 4.58+/-0.21 mm). At the time of sacrifice, the MLDs were similar in PTA and Cryo-treated arteries, but the external elastic lamina was significantly greater after Cryo application (range 10.17+/-0.54 to 14.34+/-0.76 mm2) than after PTA (range 8.69+/-0.70 to 11.77+/-0.73 mm2, p<0.05). Cryo did not alter the luminal area or prevent neointimal growth. A time-dependent increase of both CI and CIII was observed as early as 1 week after PTA, peaking at 3 months, and declining thereafter. Cryo accentuated this increase at all time points. CONCLUSION: The application of Cryo accentuates the accumulation of CI and CIII in PTA-treated femoral arteries. This effect may be of clinical relevance in the stabilization of peripheral atherosclerotic plaque.
Jean-François Dorval; Pascale Geoffroy; Martin G Sirois; Jean-François Tanguay
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists     Volume:  13     ISSN:  1526-6028     ISO Abbreviation:  J. Endovasc. Ther.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-31     Completed Date:  2006-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100896915     Medline TA:  J Endovasc Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  104-10     Citation Subset:  IM    
Research Center and Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada.
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MeSH Terms
Angioplasty, Balloon / methods*
Collagen Type I / metabolism*
Collagen Type III / metabolism*
Femoral Artery / anatomy & histology,  metabolism
Time Factors
Reg. No./Substance:
0/Collagen Type I; 0/Collagen Type III

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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