| Endovascular cryotherapy accentuates the accumulation of the fibrillar collagen types I and III after percutaneous transluminal angioplasty in pigs. | |
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MedLine Citation:
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PMID: 16445314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the effect of endovascular cryotherapy (Cryo) on the density of collagen types I (CI) and III (CIII), which are involved in the dynamic modulation of extracellular matrix (ECM) after percutaneous transluminal angioplasty (PTA). METHODS: Twenty-one juvenile farm swine and 10 miniswine underwent PTA of the femoral arteries with and without Cryo (-50 degrees C for 2 minutes). Quantitative angiography, histomorphometry, and quantification of CI and CIII were performed at 1 week (n=7), 1 month (n=7), 3 months (n=7), and 6 months (n=10). RESULTS: PTA decreased the minimal luminal diameter (MLD) (range 3.48+/-0.18 to 4.2+/-0.39 mm) compared to baseline values (range 3.67+/-0.15 to 4.59+/-0.23 mm), but the application of Cryo maintained the MLDs at preprocedural levels (range 3.88+/-0.31 to 4.58+/-0.21 mm). At the time of sacrifice, the MLDs were similar in PTA and Cryo-treated arteries, but the external elastic lamina was significantly greater after Cryo application (range 10.17+/-0.54 to 14.34+/-0.76 mm2) than after PTA (range 8.69+/-0.70 to 11.77+/-0.73 mm2, p<0.05). Cryo did not alter the luminal area or prevent neointimal growth. A time-dependent increase of both CI and CIII was observed as early as 1 week after PTA, peaking at 3 months, and declining thereafter. Cryo accentuated this increase at all time points. CONCLUSION: The application of Cryo accentuates the accumulation of CI and CIII in PTA-treated femoral arteries. This effect may be of clinical relevance in the stabilization of peripheral atherosclerotic plaque. |
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Authors:
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Jean-François Dorval; Pascale Geoffroy; Martin G Sirois; Jean-François Tanguay |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists Volume: 13 ISSN: 1526-6028 ISO Abbreviation: J. Endovasc. Ther. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-31 Completed Date: 2006-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100896915 Medline TA: J Endovasc Ther Country: United States |
Other Details:
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Languages: eng Pagination: 104-10 Citation Subset: IM |
Affiliation:
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Research Center and Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon
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methods* Animals Collagen Type I / metabolism* Collagen Type III / metabolism* Cryotherapy* Femoral Artery / anatomy & histology, metabolism Swine Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Collagen Type I; 0/Collagen Type III |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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