Document Detail

Endovascular coiling of intracranial aneurysms using bioactive coils: a single-center study.
MedLine Citation:
PMID:  17520435     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Some degree of recanalization is reported in up to one-third of intracranial aneurysms treated with endovascular coiling. A technical development potentially effective in avoiding recanalization is the Matrix Detachable Coil (MDC), which is covered with a biodegradable polymeric material that enhances intra-aneurysmal clot organization and fibrosis.
PURPOSE: To report the initial clinical experience of MDC for endovascular aneurysm coiling in a single-center, single-operator, and well-defined population setting.
MATERIAL AND METHODS: 118 aneurysms in 104 patients (73 with subarachnoid hemorrhage, SAH) were embolized with MDC alone (n = 52) or combined with bare platinum coils (n = 66).
RESULTS: Initial aneurysm obliteration was class 1 (complete obliteration) in 45 aneurysms (38.1%), class 2 (residual neck) in 44 (37.3%), and class 3 (residual aneurysm) in 29 (24.6%). Procedure-related morbidity was 4.8%, and mortality 0.96%. Clinical follow-up of 61 patients with SAH (mean 5.9 months, range 1-17 months) showed good outcome (Glasgow Outcome Scale, GOS 4-5) in 39 (63.9%), and poor outcome or death (GOS 1-3) in 22 (36.1%). Imaging follow-up of 73 aneurysms (average 6.5 months, range 1-17 months) showed class 1 in 47 (64.4%), class 2 in 18 (24.7%), and class 3 in eight (10.9%). Recanalization occurred in 11 aneurysms (15%), of which four (5.5%) required re-treatment.
CONCLUSION: This study confirms that aneurysm coiling with MDC is feasible, effective, and safe.
S Rossitti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  48     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-23     Completed Date:  2007-07-27     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  565-76     Citation Subset:  IM    
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MeSH Terms
Absorbable Implants
Aged, 80 and over
Embolization, Therapeutic / adverse effects,  instrumentation,  methods*
Intracranial Aneurysm / therapy*
Magnetic Resonance Angiography
Middle Aged
Subarachnoid Hemorrhage / therapy
Tomography, X-Ray Computed
Treatment Outcome
Comment In:
Acta Radiol. 2007 Jun;48(5):474-5   [PMID:  17520420 ]

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