| Endovascular brachytherapy for prophylaxis of restenosis after femoropopliteal angioplasty: five-year follow-up--prospective randomized study. | |
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MedLine Citation:
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PMID: 16926331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report the 5-year results from the prospective randomized Vienna-2 trial, which was designed to evaluate the safety and effectiveness of adjunctive endovascular brachytherapy (EBT) compared with no further treatment after successful revascularization in patients with long-segment femoropopliteal lesions. MATERIALS AND METHODS: Each patient gave written informed consent to participate in the study, which was approved by the hospital's ethics committee. One hundred two patients (men, 53.9%; mean age, 72.1 years +/- 8.7 [standard deviation]; lesion length, 8.1 cm +/- 4.9) underwent percutaneous transluminal angioplasty (PTA) without further stent implantation. Patients were then assigned to either receive EBT (n = 51) by using an iridium 192 source, with a prescribed dose of 12 Gy at 3 mm from the source axis, or no further treatment (n = 51). Radiation was delivered without a centering catheter. Data were analyzed by using a Student t test for continuous values and a chi(2) test to compare categorical values. A Cox proportional hazards regression analysis was performed to evaluate predictors of recurrence at follow-up. RESULTS: After 6 months, the restenosis rate for the 102 patients with completed 5-year follow-up was significantly reduced for the PTA plus EBT group versus the PTA alone group (29.4% vs 56.9%, P < .05). During follow-up we observed a late catch-up phenomenon, and after 5 years the recurrence rate was comparable in both groups (72.5% vs 72.5%, P > .99). Time to recurrence, however, was significantly delayed in the PTA plus EBT group (17.5 months +/- 14.7 vs 7.4 months +/- 6.8 for the PTA alone group, P < .05). CONCLUSION: At 5-year follow-up, PTA followed by gamma radiation EBT with a dose of 12 Gy resulted in a delay but not an inhibition of restenosis when compared with that of PTA alone. |
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Authors:
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Roswitha M Wolfram; Alexandra C Budinsky; Boris Pokrajac; Richard Potter; Erich Minar |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Radiology Volume: 240 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-23 Completed Date: 2006-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 878-84 Citation Subset: AIM; IM |
Copyright Information:
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(c) RSNA, 2006. |
Affiliation:
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Department of Angiology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria. rmwolfram@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angioplasty* Arterial Occlusive Diseases / prevention & control, therapy* Brachytherapy / methods* Female Femoral Artery* Follow-Up Studies Humans Male Middle Aged Popliteal Artery* Prospective Studies Recurrence Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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