| Endovascular treatment of side wall aneurysms using a liquid embolic agent: a US single-center prospective trial. | |
| | |
MedLine Citation:
|
PMID: 20729667 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVE: Onyx HD-500 is a liquid embolic agent consisting of ethylene vinyl alcohol copolymer dissolved in dimethylsulfoxide and mixed with tantalum. This viscous embolic agent was designed to treat intracranial side wall aneurysms, but there have been no prospective published series from the United States. From this early experience, we developed several protocol revisions, technical details, and clinical pearls that have not been published for liquid embolic embolization of aneurysms. CLINICAL PRESENTATION: We present our single-center prospective series of patients treated with Onyx HD-500 from a multicenter, randomized, controlled trial. Thirteen patients received Onyx HD-500, and their ages ranged from 43 to 81 years. Twelve patients had aneurysms on the internal carotid artery, and 1 patient had an aneurysm the vertebral artery. Every patient had an immediate postangiographic result with 90% or more occlusion by an independent core laboratory assessment. In 1 patient, the Onyx HD-500 injection was aborted, and the aneurysm was embolized with coils. Eleven of 13 patients (85%) underwent 6-month follow-up angiography that demonstrated persistent durable occlusion with no recanalization. There was 1 complication (8%) and no deaths. CONCLUSION: This is the only prospective series of intracranial aneurysms treated with Onyx HD-500 in the United States. This is also the first publication that describes detailed procedure techniques, recommended protocol revisions, lessons learned from early complications, clinical pearls, and advantages and disadvantages of liquid embolic embolization of aneurysms. |
| | |
Authors:
|
Scott D Simon; Eric Eskioglu; Adam Reig; Robert A Mericle |
Related Documents
:
|
13679267 - Hydroxyapatite ceramics as a particulate embolic material: report of the clinical exper... 8559287 - The safety and effectiveness of brain arteriovenous malformation embolization using acr... 8652427 - Immunohistochemical identification of syncytiotrophoblastic cells and megakaryocytes in... 2332327 - Stroke due to paradoxical embolism. 12231597 - Carotid artery stenting in the first 100 consecutive patients: results and follow up. 20599197 - Association of c-reactive protein and homocysteine with subclinical coronary plaque sub... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Neurosurgery Volume: 67 ISSN: 1524-4040 ISO Abbreviation: Neurosurgery Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-23 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: United States |
Other Details:
|
Languages: eng Pagination: 855-60; discussion 860 Citation Subset: IM |
Affiliation:
|
Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2380, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vestibular schwannoma.
Next Document: Faculty priorities, scholarly products, and strategic outcomes.