Document Detail

Endovascular treatment of resistant and uncontrolled hypertension: therapies on the horizon.
MedLine Citation:
PMID:  23266234     Owner:  NLM     Status:  MEDLINE    
The treatment of resistant hypertension has undergone remarkable advancements in recent years. Endovascular radio frequency renal sympathetic denervation (RSD) has shown initial success in treating resistant hypertension by targeting the connection between the brain and renal sympathetic nerves. However, the encouraging results of first-generation RSD have been tempered by important procedural limitations and a need for long-term results of safety and efficacy. In an effort to build on early clinical success, several second-generation RSD technologies are now being developed that may improve procedural safety and efficacy. Preliminary evidence for some of the latest technologies is now available. In this review, we summarize the current evidence in support of RSD and consider unique features of several new technologies that are likely to refine the endovascular treatment of resistant hypertension.
Matthew C Bunte; Eduardo Infante de Oliveira; Mehdi H Shishehbor
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-12-19
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  6     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-07-09     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects*
Catheter Ablation
Drug Resistance*
Endovascular Procedures* / adverse effects,  instrumentation
Equipment Design
Hypertension / diagnosis,  drug therapy,  physiopathology,  surgery,  therapy*
Kidney / innervation*
Sympathectomy / adverse effects,  instrumentation,  methods*
Treatment Failure
Ultrasonic Therapy
Reg. No./Substance:
0/Antihypertensive Agents

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