Document Detail


An endovascular canine middle cerebral artery occlusion model for the study of leptomeningeal collateral recruitment.
MedLine Citation:
PMID:  20856126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This work aimed to refine a large animal in minimally invasive reversible middle cerebral artery (MCA) occlusion (MCAO) model to account for leptomeningeal collateral formation.
MATERIALS AND METHODS: An angiographically based methodology allowed for transient MCA and carotid terminus occlusion in 12 mongrel dogs and assessment of pial collateral recruitment. Outcome measures included 1- and 24-hour magnetic resonance imaging-based infarct volume calculation, a behavioral scale and histopathologic sections.
RESULTS: MCAO succeeded in 8 of 12 dogs (67% efficiency). One-hour postreperfusion infarct volume predicted 24-hour postreperfusion infarct volume (r = 0.997, P < 0.0001). Pial collateral recruitment varied with time and reproducibly assessed predicted infarct volume on 1-hour postreperfusion mean diffusivity maps (P < 0.0001; r = 0.946) and 24-hour fluid-attenuated inversion recovery FLAIR magnetic resonance imaging (P = 0.0033; r = 0.961). The canine stroke scale score correlated with infarct volumes and pial collateral score.
CONCLUSION: This canine MCAO model produces defined cerebral infarct lesions whose volumes correlate with leptomeningeal collateral formation and canine behavior.
Authors:
Gregory A Christoforidis; Cameron Rink; Marinos S Kontzialis; Yousef Mohammad; Regina M Koch; Amir M Abduljalil; Valerie K Bergdall; Sashwati Roy; Savita Khanna; Andrew P Slivka; Michael V Knopp; Chandan K Sen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  46     ISSN:  1536-0210     ISO Abbreviation:  Invest Radiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-04-05     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiography
Animals
Anticoagulants / therapeutic use
Brain Ischemia / diagnosis*,  pathology,  therapy
Carotid Arteries / pathology*
Disease Models, Animal
Dogs
Feasibility Studies
Heparin / therapeutic use
Infarction, Middle Cerebral Artery / diagnosis*,  pathology,  therapy
Middle Cerebral Artery / pathology*
Multivariate Analysis
Platelet Aggregation Inhibitors / therapeutic use
Statistics as Topic
Ticlopidine / analogs & derivatives,  therapeutic use
Grant Support
ID/Acronym/Agency:
NS42617/NS/NINDS NIH HHS; R01 NS042617/NS/NINDS NIH HHS; UL1 RR025755/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Platelet Aggregation Inhibitors; 9005-49-6/Heparin; A74586SNO7/clopidogrel; OM90ZUW7M1/Ticlopidine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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