Document Detail


Endotracheal nebulization of N-acetylcysteine increases airway resistance in cats with experimental asthma.
MedLine Citation:
PMID:  21145769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
N-acetylcysteine (NAC), a mucolytic and antioxidant, is speculated to cause bronchoconstriction in cats when delivered via aerosol. We hypothesized that in cats with experimental asthma, aerosol delivery of NAC (400mg cumulative dose) via an endotracheal tube would increase airflow limitation as measured by ventilator-acquired mechanics. After endotracheal drug delivery, airway resistance and inspiratory plateau pressure (Pplat) measurements were obtained in six mechanically ventilated asthmatic cats. Results demonstrated significantly increased airway resistance (P=0.0007) compared with aerosolized saline control; Pplats were not significantly different (P=0.059). All cats exhibited at least one adverse effect: excessive airway secretions (n=3), spontaneous cough (n=2), unilateral strabismus (n=1) and post-anesthetic death (n=1). No adverse reactions were noted with saline aerosol; cough was noted in one cat with methacholine challenge. In conclusion, airway resistance and adverse reactions were documented in all cats after NAC aerosol delivery. Further studies must be performed to evaluate if it is an effective mucolytic and/or antioxidant in cats and to determine if bronchodilator pre-treatment will negate NAC-induced bronchoconstriction.
Authors:
Carol R Reinero; Tekla M Lee-Fowler; John R Dodam; Leah A Cohn; Amy E DeClue; Vamsi P Guntur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-09
Journal Detail:
Title:  Journal of feline medicine and surgery     Volume:  13     ISSN:  1532-2750     ISO Abbreviation:  J. Feline Med. Surg.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-04-04     Revised Date:  2011-09-22    
Medline Journal Info:
Nlm Unique ID:  100897329     Medline TA:  J Feline Med Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 East Campus Drive, Columbia, MO 65211, USA. reineroc@missouri.edu
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / administration & dosage,  adverse effects,  pharmacology*
Aerosols
Airway Resistance / drug effects*
Animals
Antioxidants / pharmacology
Asthma / drug therapy,  veterinary*
Bronchoconstriction / drug effects
Cats
Disease Models, Animal
Drug Delivery Systems / methods,  veterinary*
Expectorants / administration & dosage,  adverse effects,  pharmacology*
Female
Intubation, Intratracheal / veterinary
Male
Treatment Outcome
Chemical
Reg. No./Substance:
0/Aerosols; 0/Antioxidants; 0/Expectorants; 616-91-1/Acetylcysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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