| Endotracheal administration of lidocaine inhibits isoflurane-induced tachycardia. | |
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MedLine Citation:
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PMID: 10051936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Rapid increase in inspired isoflurane concentration increases heart rate and arterial blood pressure. To investigate whether the responses to isoflurane were elicited from stimulation of lower airway and/or lungs, haemodynamic responses to isoflurane administered after tracheal intubation were measured with or without endotracheal or intravenous administration of lidocaine. METHODS: Seventy-two ASA physical status 1 patients, aged 21-50 yr, were randomly allocated to one of four groups. After tracheal intubation, anaesthesia was maintained with oxygen 100% and isoflurane 1.0% with controlled ventilation. After stabilization for 15 min, the isoflurane concentration was rapidly increased to 3.0% in three groups. An endotracheal lidocaine group received pretreatment with endotracheal 0.4 ml lidocaine 8% spray, an intravenous lidocaine group received pretreatment of 32 mg lidocaine i.v., and an isoflurane 3% group received not pre- treatment. In a control group, inspired isoflurane concentration was maintained at 1.0%. Heart rate, systolic blood pressure and end-tidal isoflurane concentration were measured every minute for 10 min. RESULTS: The rapid increase in isoflurane concentration increased heart rate (25 +/- 12% increase from baseline; P < 0.05) but the increase was reduced by endotracheal lidocaine (9 +/- 9%), but not by intravenous lidocaine (22 +/- 13%). The plasma concentration of lidocaine was lower in the endotracheal lidocaine group (0.4 +/- 0.3 microgram.ml-1) than in the i.v. lidocaine group (1.5 +/- 0.2 micrograms.ml-1). CONCLUSION: The isoflurane-induced tachycardia is reduced by pre-treatment with endotracheal lidocaine. |
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Authors:
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K Takakura; Y Sugiura; K Takeuchi; Y Goto |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Canadian journal of anaesthesia = Journal canadien d'anesthésie Volume: 45 ISSN: 0832-610X ISO Abbreviation: Can J Anaesth Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-04-27 Completed Date: 1999-04-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701709 Medline TA: Can J Anaesth Country: CANADA |
Other Details:
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Languages: eng Pagination: 1181-5 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Reanimatology, Fukui Medical University, Japan. takakura@fmsrsa.fukui-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Aerosols Anesthetics, Inhalation / administration & dosage, adverse effects*, analysis Anesthetics, Local / administration & dosage*, blood Blood Pressure / drug effects Bronchi / drug effects Female Heart Rate / drug effects Humans Injections, Intravenous Intubation, Intratracheal Isoflurane / administration & dosage, adverse effects*, analysis Lidocaine / administration & dosage*, blood Lung / drug effects Male Middle Aged Respiration, Artificial Tachycardia / chemically induced, prevention & control* Tidal Volume |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Anesthetics, Inhalation; 0/Anesthetics, Local; 137-58-6/Lidocaine; 26675-46-7/Isoflurane |
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