Document Detail

Endotracheal administration of lidocaine inhibits isoflurane-induced tachycardia.
MedLine Citation:
PMID:  10051936     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Rapid increase in inspired isoflurane concentration increases heart rate and arterial blood pressure. To investigate whether the responses to isoflurane were elicited from stimulation of lower airway and/or lungs, haemodynamic responses to isoflurane administered after tracheal intubation were measured with or without endotracheal or intravenous administration of lidocaine. METHODS: Seventy-two ASA physical status 1 patients, aged 21-50 yr, were randomly allocated to one of four groups. After tracheal intubation, anaesthesia was maintained with oxygen 100% and isoflurane 1.0% with controlled ventilation. After stabilization for 15 min, the isoflurane concentration was rapidly increased to 3.0% in three groups. An endotracheal lidocaine group received pretreatment with endotracheal 0.4 ml lidocaine 8% spray, an intravenous lidocaine group received pretreatment of 32 mg lidocaine i.v., and an isoflurane 3% group received not pre- treatment. In a control group, inspired isoflurane concentration was maintained at 1.0%. Heart rate, systolic blood pressure and end-tidal isoflurane concentration were measured every minute for 10 min. RESULTS: The rapid increase in isoflurane concentration increased heart rate (25 +/- 12% increase from baseline; P < 0.05) but the increase was reduced by endotracheal lidocaine (9 +/- 9%), but not by intravenous lidocaine (22 +/- 13%). The plasma concentration of lidocaine was lower in the endotracheal lidocaine group (0.4 +/- 0.3 than in the i.v. lidocaine group (1.5 +/- 0.2 CONCLUSION: The isoflurane-induced tachycardia is reduced by pre-treatment with endotracheal lidocaine.
K Takakura; Y Sugiura; K Takeuchi; Y Goto
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  45     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-04-27     Completed Date:  1999-04-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1181-5     Citation Subset:  IM    
Department of Anesthesiology and Reanimatology, Fukui Medical University, Japan.
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MeSH Terms
Administration, Inhalation
Anesthetics, Inhalation / administration & dosage,  adverse effects*,  analysis
Anesthetics, Local / administration & dosage*,  blood
Blood Pressure / drug effects
Bronchi / drug effects
Heart Rate / drug effects
Injections, Intravenous
Intubation, Intratracheal
Isoflurane / administration & dosage,  adverse effects*,  analysis
Lidocaine / administration & dosage*,  blood
Lung / drug effects
Middle Aged
Respiration, Artificial
Tachycardia / chemically induced,  prevention & control*
Tidal Volume
Reg. No./Substance:
0/Aerosols; 0/Anesthetics, Inhalation; 0/Anesthetics, Local; 137-58-6/Lidocaine; 26675-46-7/Isoflurane

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