Document Detail

Endotoxin transfer through dialysis membranes: small- versus large-pore membranes.
MedLine Citation:
PMID:  1317524     Owner:  NLM     Status:  MEDLINE    
In this in-vivo study, dialysate and serum endotoxin was evaluated before and after haemodialysis with small-pore (PS400) and large-pore (PS600) polysulphone dialysers, and before and after haemodiafiltration with the PS600 filter. The source of the endotoxin was the presence in dialysate of Pseudomonads at a concentration of 10(3)-10(4) CFU/ml. Endotoxin was measured by a modified chromogenic limulus amoebocyte lysate (LAL) assay. In spite of dialysate endotoxin concentrations greater than 100 pg/ml, no changes in pre- versus posttreatment LAL reactivity were observed in PS400 dialysis and PS600 haemodiafiltration. In contrast, PS600 haemodialysis was related to an increase in serum LAL reactivity from 1.3 +/- 1.5 to 3.8 +/- 2.0 pg/ml (n = 15, P less than 0.01), and five patients (33.3%) showed a post-dialysis value in excess of 5 pg/ml. Our data are consistent with the absence of in-vivo endotoxin transfer during haemodialysis with small-pore dialyser membranes, and during haemodiafiltration with membranes with larger pores. An increase in LAL reactivity during haemodialysis with membranes with larger pores is, however, present, presumably due to the occurrence of backdiffusion/filtration with that specific strategy.
R Vanholder; E Van Haecke; N Veys; S Ringoir
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  7     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-29     Completed Date:  1992-06-29     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  333-9     Citation Subset:  IM    
Nephrology Department, University Hospital, Ghent, Belgium.
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MeSH Terms
Endotoxins / blood,  isolation & purification*
Hemofiltration / adverse effects
Kidney, Artificial*
Limulus Test
Membranes, Artificial*
Middle Aged
Renal Dialysis / adverse effects*
Reg. No./Substance:
0/Endotoxins; 0/Membranes, Artificial; 0/Polymers; 0/Sulfones; 25135-51-7/polysulfone P 1700

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