| Endotoxin sensitivity and immune competence in chronic heart failure. | |
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MedLine Citation:
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PMID: 15115685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Raised concentrations of endotoxin (lipopolysaccharide, LPS) are found in patients with chronic heart failure (CHF). Tolerance of monocytes to LPS can be induced by LPS itself resulting in a downregulation of cytokine response to LPS challenge. This phenomenon of LPS desensitization has also been suggested for CHF. METHODS: We investigated whether CHF patients really show a desensitization to LPS stimuli at rest or after physical exercise, which was used as a model of limited inflammatory reaction. Thirty-five patients with CHF (59+/-12 years, 8 women) and 30 healthy control subjects were prospectively studied with cardiopulmonary exercise testing. At rest and directly after exercise blood samples were taken for the quantitative determination of HLA-DR expression of monocytes as a measure for immune competence and for the measurement of TNFalpha generation after ex vivo stimulation by LPS. RESULTS: HLA-DR expression was comparable in CHF patients and controls at rest as well as after exercise. TNFalpha production by LPS-stimulated monocytes ex vivo was higher in CHF patients compared to controls at rest and after exercise. CONCLUSIONS: Thus, our data are the first to show that patients with stable CHF show a cellular hypersensitivity to LPS with a higher TNFalpha generation capacity at rest and after exercise compared to controls. CHF patients seem to have a marked susceptibility to low inflammatory stimuli and no desensitization to LPS. |
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Authors:
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Stefan Krüger; Dagmar Kunz; Jürgen Graf; Tina Stickel; Marc W Merx; Peter Hanrath; Uwe Janssens |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 343 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-29 Completed Date: 2004-12-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 135-9 Citation Subset: IM |
Affiliation:
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Medical Clinic I, University Hospital, University of Technology, Aachen, Germany. skrueger@ukaachen.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female HLA-DR Antigens / immunology, metabolism Heart Diseases / blood, immunology* Heart Failure / blood, immunology Humans Lipopolysaccharides / pharmacology* Male Middle Aged Monocytes / immunology, metabolism, secretion Tumor Necrosis Factor-alpha / secretion |
| Chemical | |
Reg. No./Substance:
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0/HLA-DR Antigens; 0/Lipopolysaccharides; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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