Document Detail


Endotoxin protection against oxygen toxicity and its reversal by acetylsalicylic acid.
MedLine Citation:
PMID:  3079688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the involvement of substances derived from arachidonic acid in the mechanism of endotoxin's protective action against pulmonary oxygen toxicity. Eighty-three percent of rats treated with a small dose of endotoxin (1 mg/kg) survived exposure to over 95% oxygen for 7 days. In contrast, all control rats exposed to the same oxygen concentration died within 3 days. When the endotoxin-treated rats were also treated with the soluble lysine salt of acetylsalicylic acid (100 mg/kg), 7-day survival decreased to 25%. This suggests that prostaglandin metabolism may play an important role in the protective action of endotoxin during hyperoxia.
Authors:
J Klein; A Trouwborst; P J Salt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  14     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-02-05     Completed Date:  1986-02-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  32-3     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspirin / analogs & derivatives*,  pharmacology
Endotoxins / antagonists & inhibitors,  therapeutic use*
Lysine / analogs & derivatives*,  pharmacology
Male
Oxygen / poisoning*
Rats
Rats, Inbred Strains
Salmonella typhimurium*
Chemical
Reg. No./Substance:
0/Endotoxins; 37933-78-1/acetylsalicylic acid lysinate; 50-78-2/Aspirin; 56-87-1/Lysine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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