Document Detail

Endotoxin levels in cow's milk samples from farming and non-farming families - the PASTURE study.
MedLine Citation:
PMID:  18502510     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Children from farming families have less allergies than their peers. Consumption of farm milk or unpasteurized milk has been shown to explain (part of) the farming effect or protect against allergies independent of farming status. OBJECTIVES: We investigated whether the protective effect of farm milk consumption can be explained by higher levels of bacterial endotoxin in milk. METHODS: We measured endotoxin in approximately 400 farm milk and shop milk samples from farming and non-farming families, respectively, with the kinetic chromogenic Limulus Amebocyte Lysate test and compared endotoxin levels between groups defined by farming status and type of milk (farm milk/shop milk). RESULTS: Endotoxin levels were significantly higher in milk samples from non-farming families compared to farming families [adjusted geometric means ratio (95% confidence interval)=2.61 (1.53-4.43)]. No significant difference in endotoxin levels was found between shop milk and farm milk samples [adjusted geometric means ratio (95% confidence interval)=1.56 (0.94-2.58)]. The difference between farming and non-farming families could be explained completely for farm milk and partially for shop milk by storage conditions and temperature during transportation to the fieldworker's home. CONCLUSION: The farming effect and the effect of farm milk consumption cannot be explained by higher levels of endotoxin in milk from farmers and farm milk, respectively.
Ulrike Gehring; Jack Spithoven; Susanne Schmid; Sondhja Bitter; Charlotte Braun-Fahrländer; Jean-Charles Dalphin; Anne Hyvärinen; Juha Pekkanen; Josef Riedler; Stephan K Weiland; Gisela Büchele; Erika von Mutius; Dominique A Vuitton; Bert Brunekreef;
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-27
Journal Detail:
Title:  Environment international     Volume:  34     ISSN:  0160-4120     ISO Abbreviation:  Environ Int     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2009-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807270     Medline TA:  Environ Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1132-6     Citation Subset:  IM    
Utrecht University, Institute for Risk Assessment Sciences, Utrecht, The Netherlands.
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MeSH Terms
Endotoxins / analysis*
Milk / chemistry*
Reg. No./Substance:
E von Mutius / ; M Kabesch / ; S Kraus-Etschmann / ; S Maier / ; S Schmid / ; M Ege / ; H Roiha / ; C Braun-Fahrländer / ; S Bitter / ; M Waser / ; J Riedle / ; C Hummer / ; E Ublagger / ; G Weiss / ; J Pekkanen / ; M-R Hirvonen / ; M Roponen / ; K Huttunen / ; A Hyvärinen / ; A Nevalainen / ; S Remes / ; T-P Tuomainen / ; B Brunekreef / ; J Douwes / ; U Gehring / ; R Massoud / ; H Renz / ; N Blümer / ; I Herzum / ; R Lauener / ; D Steinhoff / ; R Frei / ; J Steinle / ; S Loeliger / ; S Weiland / ; G Büchele / ; D Vuitton / ; J-C Dalphin / ; M-L Dalphin / ; R Piarroux / ; L Millon / ; G Reboux / ; S Roussel / ; B Sudre /

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