| Endotoxin levels in cirrhotic rats with sterile and infected ascites. | |
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MedLine Citation:
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PMID: 1624078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endotoxin levels were measured in sterile and bacterially infected ascites in a rat model of phenobarbital and carbon tetrachloride induced cirrhosis was used. An improved chromogenic substrate assay was used to measure endotoxin. All rat ascites specimens were positive for endotoxin. In culture-negative ascites (n = 8), it ranged from 0.05 EU/ml to 0.14 EU/ml (0.08 +/- 0.04 EU/ml, mean +/- SD) (Escherichia coli 0111:B4 endotoxin was used as a reference). In culture-positive ascites (premortem n = 3, postmortem n = 1), it ranged from 0.78 EU/ml to 1.8 EU/ml (1.29 +/- 0.59 EU/ml, mean +/- SD). All rats with premortem culture-positive ascites died within two days. This model is useful to study ascites endotoxin levels. In this study, increasing levels of ascites endotoxin correlated with spontaneous bacterial peritonitis and death. |
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Authors:
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S Sugano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastroenterologia Japonica Volume: 27 ISSN: 0435-1339 ISO Abbreviation: Gastroenterol. Jpn. Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-08-12 Completed Date: 1992-08-12 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0152744 Medline TA: Gastroenterol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 348-53 Citation Subset: IM |
Affiliation:
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Saiseikai Wakakusa Hospital, Yokohama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascitic Fluid / chemistry*, pathology Chromogenic Compounds Disease Models, Animal Endotoxins / analysis* Escherichia coli* Liver Cirrhosis, Experimental* / pathology Male Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Chromogenic Compounds; 0/Endotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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