Document Detail


Endotoxin-induced myocardial dysfunction: is there a role for nitric oxide?
MedLine Citation:
PMID:  8595520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitric oxide has been implicated in the regulation of cardiac contractile function as well as the depressed myocardial contractility associated with sepsis and endotoxemia. We examined the effects of nitric oxide synthase (NOS) inhibitors and a nitric oxide generator on contractile responses of left atrial preparations and ventricular myocytes isolated from endotoxemic guinea pigs, which exhibit depressed myocardial contractile function. The NOS inhibitor L-NAME had no effect on contractile tension developed by control atria or atria isolated from guinea pigs 4 or 16 h after an intraperitoneal injection of endotoxin. Similarly, contraction of ventricular myocytes isolated from control or endotoxemic guinea pigs (4 h after endotoxin injection) was unchanged by exposure to several NOS inhibitors. In addition, neither Ca(2+)-dependent nor Ca(2+)-independent ventricular NOS activity was affected by endotoxemia. These data suggest that nitric oxide alone is not responsible for the cardiac contractile dysfunction of endotoxemic guinea pigs.
Authors:
R S Keller; J J Jones; K F Kim; P R Myers; H R Adams; J L Parker; L J Rubin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  4     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-04-17     Completed Date:  1996-04-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  338-44     Citation Subset:  IM    
Affiliation:
Department of Veterinary Biomedical Science, University of Missouri-Columbia 65211, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine / analogs & derivatives,  pharmacology
Enzyme Inhibitors / pharmacology*
Guanidines / pharmacology
Guinea Pigs
Heart Atria / drug effects,  metabolism,  physiopathology*
Immunoenzyme Techniques
Lipopolysaccharides
Male
Myocardial Contraction / drug effects*
Myocardium / enzymology,  metabolism*
NG-Nitroarginine Methyl Ester
Nitric Oxide / metabolism
Nitric Oxide Synthase / antagonists & inhibitors*
Shock, Septic / chemically induced,  metabolism,  physiopathology*
omega-N-Methylarginine
Grant Support
ID/Acronym/Agency:
R01-HL36079/HL/NHLBI NIH HHS; R15-HL50082/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Guanidines; 0/Lipopolysaccharides; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; 79-17-4/pimagedine; EC 1.14.13.39/Nitric Oxide Synthase

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