| Endotoxin-induced myocardial dysfunction: is there a role for nitric oxide? | |
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MedLine Citation:
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PMID: 8595520 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide has been implicated in the regulation of cardiac contractile function as well as the depressed myocardial contractility associated with sepsis and endotoxemia. We examined the effects of nitric oxide synthase (NOS) inhibitors and a nitric oxide generator on contractile responses of left atrial preparations and ventricular myocytes isolated from endotoxemic guinea pigs, which exhibit depressed myocardial contractile function. The NOS inhibitor L-NAME had no effect on contractile tension developed by control atria or atria isolated from guinea pigs 4 or 16 h after an intraperitoneal injection of endotoxin. Similarly, contraction of ventricular myocytes isolated from control or endotoxemic guinea pigs (4 h after endotoxin injection) was unchanged by exposure to several NOS inhibitors. In addition, neither Ca(2+)-dependent nor Ca(2+)-independent ventricular NOS activity was affected by endotoxemia. These data suggest that nitric oxide alone is not responsible for the cardiac contractile dysfunction of endotoxemic guinea pigs. |
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Authors:
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R S Keller; J J Jones; K F Kim; P R Myers; H R Adams; J L Parker; L J Rubin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: 4 ISSN: 1073-2322 ISO Abbreviation: Shock Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-04-17 Completed Date: 1996-04-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 338-44 Citation Subset: IM |
Affiliation:
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Department of Veterinary Biomedical Science, University of Missouri-Columbia 65211, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / analogs & derivatives, pharmacology Enzyme Inhibitors / pharmacology* Guanidines / pharmacology Guinea Pigs Heart Atria / drug effects, metabolism, physiopathology* Immunoenzyme Techniques Lipopolysaccharides Male Myocardial Contraction / drug effects* Myocardium / enzymology, metabolism* NG-Nitroarginine Methyl Ester Nitric Oxide / metabolism Nitric Oxide Synthase / antagonists & inhibitors* Shock, Septic / chemically induced, metabolism, physiopathology* omega-N-Methylarginine |
| Grant Support | |
ID/Acronym/Agency:
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R01-HL36079/HL/NHLBI NIH HHS; R15-HL50082/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Guanidines; 0/Lipopolysaccharides; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; 79-17-4/pimagedine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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