Document Detail

Endotoxin-induced lung injury in unanesthetized sheep: effect of methylprednisolone.
MedLine Citation:
PMID:  7249263     Owner:  NLM     Status:  MEDLINE    
Our purpose was to study the effect of methylprednisolone (MPS) on endotoxin-induced lung injury. We used lung lymph flow and lymph protein content at sensitive indicators of pulmonary microvascular integrity in unanesthetized sheep. Seven animals were given E coli endotoxin (2 micrograms/kg) alone and also endotoxin with MPS pretreatment (30 mg/kg) in paired separate studies. The endotoxin injury was divided into an early hypertensive phase (30-90 minutes) characterized by a significant increase in pulmonary artery pressure (Ppa) and lymph flow, QL. This was followed later (3-5 hours) by a significant increase in protein-rich QL with normal pressures. MPS pretreatment significantly increased both injury phases in all animals. White cell count decreased in both groups; however, lymph beta-glucuronidase increased only in the nontreated group. Platelet count decreased in the nontreated group. Seven animals were then compared using endotoxin alone or with MPS treatment one hour after endotoxin. Only four of seven animals had a decrease in the lung injury after MPS treatment. We conclude that methylprednisolone is very effective in preventing lung injury, but only minimally effective in reversing the injury from endotoxin.
R H Demling; M Smith; R Gunther; T Wandzilak
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulatory shock     Volume:  8     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1981  
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  351-60     Citation Subset:  IM    
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MeSH Terms
Capillary Permeability / drug effects
Endotoxins / poisoning*
Hypertension, Pulmonary / chemically induced
Lung / drug effects*
Lymph / metabolism
Methylprednisolone / pharmacology*
Shock, Septic / physiopathology
Grant Support
Reg. No./Substance:
0/Endotoxins; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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