Document Detail


Endotoxin-induced left ventricular depression is blocked by nitrogen mustard or dimethylthiourea in rabbits.
MedLine Citation:
PMID:  7573507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined endotoxin-induced myocardial depression in 31 anesthetized rabbits using left ventricular end-systolic and end-diastolic pressure-volume relationships (sonomicrometers). In the control group, endotoxin (100 micrograms/kg iv) induced systolic depression (> 10% increase in end-systolic volume at matched end-systolic pressure) in 9 of 16 and diastolic dilation (> 10% increase in end-diastolic volume at matched end-diastolic pressure) in 8 of 16 rabbits within 7 h, unrelated to hypotension, acidosis, or hypoxia. Seven rabbits were pretreated with nitrogen mustard (1-2 mg/kg iv 4 and 2 days before) to decrease circulating neutrophils and monocytes by 98%. Endotoxin did not induce systolic depression in any rabbit (P = 0.01 compared with control), and diastolic dilation developed in one rabbit (P = 0.12). In eight rabbits pretreated with dimethylthiourea (DMTU; 500 mg/kg iv 30 min before), an intracellular free radical scavenger, systolic depression developed in one (P = 0.05) and diastolic dilation in five (P = 0.44). We conclude that cells inhibited by nitrogen mustard (e.g., neutrophils, monocytes, or macrophages) mediate endotoxin-induced left ventricular systolic depression. DMTU inhibited endotoxin-induced systolic but not diastolic dysfunction.
Authors:
Y Nishikawa; W Y Lew
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  269     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-11-02     Completed Date:  1995-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1098-105     Citation Subset:  IM    
Affiliation:
Department of Medicine, Department of Veterans Affairs Medical Center, San Diego, California 92161, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Endotoxins / pharmacology*
Female
Free Radical Scavengers / pharmacology
Male
Mechlorethamine / pharmacology*
Rabbits
Systole
Thiourea / analogs & derivatives*,  pharmacology
Ventricular Function, Left / drug effects*
Chemical
Reg. No./Substance:
0/Endotoxins; 0/Free Radical Scavengers; 51-75-2/Mechlorethamine; 61805-96-7/1,3-dimethylthiourea; 62-56-6/Thiourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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