Document Detail

Endotoxin-induced fetal growth retardation in the pregnant guinea pig.
MedLine Citation:
PMID:  8438954     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Our purpose was to test the hypothesis that bacterial endotoxin may reduce fetal growth and to assess some of the pathophysiologic mechanisms of such an effect. STUDY DESIGN: Two randomly selected groups of nine guinea pigs at 30 days' gestation were treated with a solution of endotoxin isolated from Bacteroides fragilis or with solvent alone. Antibody titers, glucose, triglycerides, and 6-keto-prostaglandin F1 alpha were determined in maternal or fetal blood samples. Fetal weight was determined at 61 days' gestation. RESULTS: Endotoxin-treated guinea pigs showed positive antiendotoxin antibody titers, reduced weight gain, and significantly higher serum levels of triglycerides and 6-keto-prostaglandin F1 alpha, but not of glucose, than did sham-treated controls. Fetuses of endotoxin-treated animals had significantly lower birth weights and serum glucose concentrations and significantly higher triglyceride levels than did control fetuses. CONCLUSIONS: Bacteroides fragilis endotoxin causes fetal growth retardation in the pregnant guinea pig, which may be due to alterations in carbohydrate and fat metabolism mediated by cytokine action.
I Beckmann; F Meisel-Mikołajczyk; P Leszczynski; M Brooijmans; H C Wallenburg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  168     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-22     Completed Date:  1993-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  714-8     Citation Subset:  AIM; IM    
Institute of Obstetrics and Gynecology, Erasmus University School of Medicine and Health Sciences, Rotterdam, The Netherlands.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / blood
Bacteroides fragilis*
Blood Glucose / analysis
Body Weight
Fetal Blood
Fetal Growth Retardation / chemically induced*,  pathology
Fetus / anatomy & histology
Guinea Pigs
Prospective Studies
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Endotoxins; 0/Triglycerides; 58962-34-8/6-Ketoprostaglandin F1 alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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