Document Detail

Endotoxin exposure in utero increases ethanol consumption in adult male offspring.
MedLine Citation:
PMID:  15106858     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies have suggested that adverse experiences in utero predispose individuals to neurobehavioral disorders including drug abuse in adulthood. The present study was designed to examine the hypothesis that maternal endotoxin exposure during pregnancy increases ethanol consumption in adult offspring. Pregnant Sprague-Dawley rats were subjected to lippopolysaccharide (LPS, 1.0 mg/kg, s.c.) treatment on alternate days throughout pregnancy. Adult male offspring were tested for ethanol consumption by using a free-access and two bottle choice paradigm. The animals exposed to LPS showed increased ethanol intake and preference as well as decreased rearing activity in the open field test. These data suggest that maternal infection during pregnancy might precipitate alcohol drinking behavior in adult offspring and this effect might be due, at least in part, to elevated levels of anxiety.
Xiu Liu; James G Lee; Susan K Yee; Catherine J Bresee; Russell E Poland; Robert N Pechnick
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroreport     Volume:  15     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-04-26     Completed Date:  2004-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
Department of Psychiatry, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
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MeSH Terms
Alcohol Drinking* / psychology
Behavior, Addictive / chemically induced*,  psychology
Endotoxins / toxicity*
Ethanol / administration & dosage*
Prenatal Exposure Delayed Effects*
Sex Factors
Grant Support
Reg. No./Substance:
0/Endotoxins; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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