| Endotoxin exposure in utero increases ethanol consumption in adult male offspring. | |
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MedLine Citation:
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PMID: 15106858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epidemiological studies have suggested that adverse experiences in utero predispose individuals to neurobehavioral disorders including drug abuse in adulthood. The present study was designed to examine the hypothesis that maternal endotoxin exposure during pregnancy increases ethanol consumption in adult offspring. Pregnant Sprague-Dawley rats were subjected to lippopolysaccharide (LPS, 1.0 mg/kg, s.c.) treatment on alternate days throughout pregnancy. Adult male offspring were tested for ethanol consumption by using a free-access and two bottle choice paradigm. The animals exposed to LPS showed increased ethanol intake and preference as well as decreased rearing activity in the open field test. These data suggest that maternal infection during pregnancy might precipitate alcohol drinking behavior in adult offspring and this effect might be due, at least in part, to elevated levels of anxiety. |
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Authors:
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Xiu Liu; James G Lee; Susan K Yee; Catherine J Bresee; Russell E Poland; Robert N Pechnick |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroreport Volume: 15 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-04-26 Completed Date: 2004-05-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 203-6 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. xiu.liu@cshs.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking*
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psychology Animals Behavior, Addictive / chemically induced*, psychology Endotoxins / toxicity* Ethanol / administration & dosage* Female Male Pregnancy Prenatal Exposure Delayed Effects* Rats Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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DA14680/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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