| Endotoxin disrupts beta-adrenergic signal transduction in the heart. | |
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MedLine Citation:
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PMID: 8304831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Nonsurvivors of septic shock demonstrate impaired myocardial function refractory to the administration of beta-agonists. METHODS: Using the isolated rat heart preparation, the integrity of the beta-adrenergic transduction pathway was tested (rate pressure product, rate of contraction, rate of relaxation, and cyclic adenosine monophosphate content) using isoproterenol hydrochloride (beta-receptor agonist) or colforsin (forskolin) (adenylyl cyclase activator) stimulation following intracoronary endotoxin infusion. RESULTS: Basal rate pressure product, rate of contraction, rate of relaxation, and cyclic adenosine monophosphate concentrations were unaffected by endotoxin infusion. Endotoxin impaired, increases in rate pressure product, rates of contraction and relaxation, and cyclic adenosine monophosphate to isoproterenol (P < .05), but the response to colforsin was unaffected by endotoxin. CONCLUSIONS: Endotoxin disrupts the myocardial response to direct beta-receptor stimulation but not to adenylyl cyclase stimulation in the isolated rat heart. CLINICAL RELEVANCE: Alteration of the proximal beta-adrenoreceptor complex by endotoxin suggests that therapy of the failing heart during refractory septic shock may be directed to intact sites distal in the beta-adrenergic pathway. |
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Authors:
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D D Bensard; A Banerjee; R C McIntyre; R L Berens; A H Harken |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of surgery (Chicago, Ill. : 1960) Volume: 129 ISSN: 0004-0010 ISO Abbreviation: Arch Surg Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1994-03-10 Completed Date: 1994-03-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9716528 Medline TA: Arch Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 198-204; discussion 204-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Colorado Health Sciences Center, Denver. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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drug effects Animals Cardiac Output / drug effects Cyclic AMP / metabolism Endotoxins / adverse effects* Forskolin / pharmacology* Heart / drug effects* Heart Rate / drug effects Isoproterenol / pharmacology* Lipopolysaccharides / adverse effects* Male Myocardial Contraction / drug effects Rats Rats, Sprague-Dawley Receptors, Adrenergic, beta / drug effects* Salmonella typhimurium* Signal Transduction / drug effects* Ventricular Pressure / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL 44186/HL/NHLBI NIH HHS; R29-H43696//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Lipopolysaccharides; 0/Receptors, Adrenergic, beta; 60-92-4/Cyclic AMP; 66428-89-5/Forskolin; 7683-59-2/Isoproterenol; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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