Document Detail

Endotoxemia in the neonatal lamb.
MedLine Citation:
PMID:  3883782     Owner:  NLM     Status:  MEDLINE    
Although gram-negative sepsis is a major cause of neonatal morbidity and mortality, our understanding of endotoxemia in the neonate has been hampered by the lack of experimental models. Previous studies have suggested neonatal hyporesponsiveness to endotoxin. We studied unanesthetized neonatal lambs which had been exposed to the environment prior to study. These animals demonstrated the classic early phase changes of endotoxemia including pulmonary hypertension which was dependent upon prostanoid production. This model allows further studies of endotoxemia in the neonate.
W F O'Brien; S M Golden; S E Davis; M C Bibro
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  151     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-23     Completed Date:  1985-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  671-4     Citation Subset:  AIM; IM    
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MeSH Terms
Animals, Newborn
Blood Gas Analysis
Disease Models, Animal
Escherichia coli
Hydrogen-Ion Concentration
Prostaglandins E / blood
Prostaglandins F / blood
Shock, Septic / blood,  etiology*
Time Factors
Reg. No./Substance:
0/Endotoxins; 0/Prostaglandins E; 0/Prostaglandins F

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