Document Detail


Endotoxemia causing fetal bradycardia during urosepsis.
MedLine Citation:
PMID:  11336765     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Fetal bradycardia is a recognized response to maternal hypothermia associated with hypoglycemia, tocolysis with magnesium sulfate, or urosepsis, and it is thought to be a direct response to the decrease in the maternal core temperature. CASE: A 25-year-old white woman, gravida 1, para 0, at 31 1/7 weeks' gestation was admitted with a diagnosis of pyelonephritis. The baseline fetal heart rate was 120 beats per minute with accelerations. Within 3 hours of admission, the patient became hypothermic (35.1C) and, concomitantly, the fetal heart rate baseline declined to 90 beats per minute with marked variability. Despite sustained maternal hypothermia, the fetal heart rate baseline rose to 120 beats per minute. It was another 6 hours before the patient's temperature rose above 38.5C. Her urine and blood cultures were positive for Serratia rubidacea infection. The patient delivered a healthy infant at 39 weeks' gestation. CONCLUSION: Fetal bradycardia in the presence of urosepsis might be due to the release of endotoxin from gram-negative bacteria, triggering production of cardiotoxic cytokines, rather than to maternal hypothermia alone.
Authors:
C Buhimschi; C P Weiner
Related Documents :
9215175 - Trauma in pregnancy: normal revised trauma score in relation to other markers of matern...
10463995 - 24-hour ecg frequency-domain measures in preeclamptic and healthy pregnant women during...
8312325 - Immunosuppressive therapy, management, and outcome of heart transplant recipients durin...
6691395 - Significant fetal bradycardia during antepartum heart rate testing.
20437535 - Movement disorders and pregnancy: a review of the literature.
9564645 - Fetal loss after early detection of heart motion in infertility patients. prognostic fa...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  97     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-04     Completed Date:  2001-05-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  818-20     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD 21201, USA. cbuhi001@umaryland.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Bacterial Agents / therapeutic use
Bradycardia / etiology*
Endotoxemia / complications,  drug therapy*
Female
Heart Rate, Fetal
Humans
Hypothermia / etiology*
Infant, Newborn
Male
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Pregnancy Outcome
Prenatal Care
Pyelonephritis / complications,  drug therapy*
Serratia Infections / complications,  drug therapy*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Breast-feeding by a cyclosporine-treated mother.
Next Document:  Fetal chylothorax response to maternal dietary treatment.