Document Detail


Endotoxemia alters splanchnic capacitance.
MedLine Citation:
PMID:  10909896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The splanchnic circulation constitutes a major portion of the total capacitance vasculature and may affect venous return and subsequently cardiac output during low output states. This study assessed the effects of rapid (10 microg/kg over 5 min) and slow (10 microg/kg over 60 min) induction of endotoxin (Escherichia coli) shock on splanchnic blood volume in 8 farm swine. Blood volume was measured by using Tc99m-labeled erythrocytes and radionuclide imaging. Baseline arterial pressure (MAP), central venous pressure (CVP), and liver, splenic, mesenteric and total splanchnic volumes were stable during the 30-min baseline. Approximately 30 min after the rapid endotoxin infusion, splenic volume decreased by 45%, whereas liver volume increased by 40% and MAP decreased by 60% (P < 0.01). The reduction in splenic volume occurred within 10 min of the endotoxin infusion, whereas liver volume changes occurred after MAP reduction. The slow endotoxin infusion also reduced splenic volume by approximately 50% (P = 0.05), whereas MAP declined by 30% (P < 0.05). However, the slow endotoxin infusion lowered liver volume (P < 0.05). Mesenteric volume was unaffected by the fast or slow endotoxin infusion. Total splanchnic volume was unaffected by the fast infusion but decreased by 37% in the slow infusion group (P < 0.05). In summary, E. coli endotoxin reduces splenic blood volume and increases liver blood volume after acute hypotension ensues. Endotoxin does not increase total splanchnic blood volume and may actually decrease total splanchnic volume in the absence of circulatory collapse. This endotoxin shock model is not associated with blood volume pooling in the splanchnic capacitance circulation.
Authors:
M R Ujhelyi; A W Miller; S Raibon; J Corley; V J Robinson; J J Sims; T Tonnessen; G Burke; A Ilebekk; D L Rutlen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  14     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-12-07     Completed Date:  2000-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  IM    
Affiliation:
University of Georgia College of Pharmacy, Medical College of Georgia Department of Medicine, Augusta, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Volume
Drug Administration Schedule
Endotoxemia / chemically induced,  physiopathology*,  radionuclide imaging
Female
Hematocrit
Hypotension / etiology
Infusions, Intravenous / methods
Lipopolysaccharides / administration & dosage,  toxicity*
Liver / blood supply
Male
Mesentery / blood supply
Shock, Septic / chemically induced,  physiopathology*,  radionuclide imaging
Splanchnic Circulation*
Spleen / blood supply
Swine
Vascular Capacitance*
Chemical
Reg. No./Substance:
0/Lipopolysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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