Document Detail

Endotherapy of early onset idiopathic chronic pancreatitis: results with long-term follow-up.
MedLine Citation:
PMID:  11923759     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Idiopathic chronic pancreatitis that presents at age 35 years or younger has been classified as early onset type and is often characterized by chronic severe pain. Endotherapy, with drainage of the main pancreatic duct, can lead to control of pain if ductal hypertension is an important cause. Long-term results of endotherapy in patients with early onset idiopathic chronic pancreatitis are reported herein. METHODS: This retrospective study consists of 11 patients (6 men, 5 women; mean age 24.2 years, range 16-34 years) treated endoscopically in a 6.5-year period. The indication for treatment was pain in all patients and all had a dilated main pancreatic duct on pancreatography. The objectives of endoscopic treatment were to obtain good drainage of the pancreatic duct and complete clearance of ductal stones. RESULTS: Treatment was successful in all patients with no procedure-related mortality and with mild complications. Seven patients remained free of pain relapses after a mean follow-up of 78.3 months (37-116 months). Seven relapses of pain were recorded in the remaining 4 patients. Endoscopic retreatment was successful in all cases. The difference between the number of hospitalizations during the year before treatment (mean 2.2, range 1-9) and the year after (mean 0.3, range 0-2) was statistically significant (p < 0.01). Statistical significance was maintained at 3 and 6 years' follow-up. CONCLUSIONS: Endoscopic treatment could be regarded as the initial management of choice for patients with early onset idiopathic chronic pancreatitis.
Armando Gabbrielli; Massimiliano Mutignani; Monica Pandolfi; Vincenzo Perri; Guido Costamagna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  55     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-29     Completed Date:  2002-04-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  488-93     Citation Subset:  IM    
Department of Digestive Diseases, Libera Università, Campus Bio Medico, and the Digestive Endoscopy Unit, Department of Surgery, Università Cattolica del Sacro Cuore, Roma, Italy.
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MeSH Terms
Chronic Disease
Drainage / methods*
Endoscopy, Gastrointestinal*
Pancreatitis / therapy*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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