| Endothelium-derived epoxyeicosatrienoic acids and vascular function. | |
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MedLine Citation:
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PMID: 16490839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epoxyeicosatrienoic acids (EETs) are epoxides of arachidonic acid generated by cytochrome P450 (CYP) epoxygenases. The activation of CYP epoxygenases in endothelial cells is an important step in the NO and prostacyclin-independent vasodilatation of several vascular beds, and EETs have been identified as an endothelium-derived hyperpolarizing factor. However, EETs also exert membrane potential-independent effects and modulate several signaling cascades that affect endothelial cell proliferation and angiogenesis. This review summarizes the role of CYP-derived EETs in endothelium-derived hyperpolarizing factor-mediated responses and highlights the evidence indicating that EETs are important second messengers involved in endothelial cell signaling pathways related to angiogenesis. |
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Authors:
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Ingrid Fleming; Rudi Busse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-02-20 |
Journal Detail:
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Title: Hypertension Volume: 47 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-24 Completed Date: 2006-04-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 629-33 Citation Subset: IM |
Affiliation:
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Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany. fleming@em.uni-frankfurt.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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8,11,14-Eicosatrienoic Acid
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analogs & derivatives* Animals Biological Factors / metabolism Blood Vessels / physiology*, physiopathology Endothelium, Vascular / metabolism* Humans Hypertension / physiopathology Vasomotor System / physiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Factors; 0/endothelium-dependent hyperpolarization factor; 7324-41-6/8,11,14-Eicosatrienoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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