Document Detail

Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog.
MedLine Citation:
PMID:  2890656     Owner:  NLM     Status:  MEDLINE    
Endothelium-dependent responses differ in arteries and veins of the dog. Experiments were performed to determine whether chronic grafting of veins into the arterial circulation would alter the endothelium-dependent responses of the veins. Segments of femoral veins were grafted to the femoral artery of the dog. 6 wk after surgery the venous grafts were removed from the dog, cut into rings, and suspended in organ chambers for isometric tension recording. In some rings the endothelial cells were removed. Acetylcholine and alpha 2-adrenergic agonists did not cause endothelium-dependent relaxations in venous grafts. The calcium ionophore (A23187) initiated such relaxations which were not mediated by prostanoids. Endothelium-dependent relaxations were also observed in venous grafts to ADP, thrombin, and arachidonic acid. In segments of graft where myo-intimal hyperplasia was prominent, relaxations to ADP, thrombin, and A23187 were blunted and in some segments contractions were observed. These results demonstrate the ability of the endothelium of venous grafts to initiate changes in tone of the smooth muscle.
V M Miller; M M Reigel; L H Hollier; P M Vanhoutte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  80     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-23     Completed Date:  1987-12-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1350-7     Citation Subset:  AIM; IM    
Department of Physiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905.
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MeSH Terms
Acetylcholine / pharmacology
Adenosine Diphosphate / pharmacology
Adrenergic alpha-Agonists / pharmacology
Arachidonic Acid
Arachidonic Acids / pharmacology
Calcimycin / pharmacology
Endothelium / physiology*
Femoral Vein / physiology,  transplantation*
Indomethacin / pharmacology
Muscle Relaxation / drug effects
Muscle, Smooth, Vascular / physiology*
Quinoxalines / pharmacology
Thrombin / pharmacology
Grant Support
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Arachidonic Acids; 0/Quinoxalines; 506-32-1/Arachidonic Acid; 51-84-3/Acetylcholine; 52665-69-7/Calcimycin; 53-86-1/Indomethacin; 58-64-0/Adenosine Diphosphate; 59803-98-4/brimonidine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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