Document Detail

Endothelium-dependent relaxations in canine coronary arteries are enhanced in early heart failure and persist in recovery.
MedLine Citation:
PMID:  7882178     Owner:  NLM     Status:  MEDLINE    
In vitro coronary artery responsiveness to noradrenaline, phenylephrine, and BHT-920 together with functional relaxation to acetylcholine was assessed in dogs at the early onset of pacing-induced heart failure (1 week) and in dogs recovered from heart failure (3 weeks paced, followed by 4 weeks discontinued pacing). alpha-Adrenoceptor stimulation produced contractile responses that were unaltered in early congestive heart failure and recovery. Contractions to noradrenaline and BHT-920 were always less than those produced by phenylephrine. Endothelium-intact arteries demonstrated relaxations in response to noradrenaline and BHT-920, but not phenylephrine. Relaxations to noradrenaline were enhanced 24% in early heart failure and 47% following recovery from heart failure, compared with control. BHT-920 produced relaxations that were augmented 21 and 76% in early heart failure and recovery, respectively. Contractile sensitivity to noradrenaline increased 5-fold in early heart failure and was not different in recovery, compared with control. Contractile sensitivity to BHT-920 and phenylephrine was unaltered throughout. Acetylcholine produced relaxations that were increased 21% in early heart failure and 13% after recovery from congestive heart failure. Furthermore, acetylcholine sensitivity was significantly enhanced in early heart failure and recovery. The current study reveals a progressive adaptation of the coronary endothelium in congestive heart failure, possibly directed towards protection against excessive vasoconstriction due to circulating catecholamines.
G Larosa; P W Armstrong; C Forster
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  72     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-04-12     Completed Date:  1995-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1148-54     Citation Subset:  IM    
Department of Medicine, St. Michael's Hospital, Toronto, ON, Canada.
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MeSH Terms
Acetylcholine / pharmacology
Adaptation, Physiological
Adrenergic alpha-Agonists / pharmacology*
Azepines / pharmacology
Coronary Vessels / metabolism,  physiopathology*
Dose-Response Relationship, Drug
Endothelium, Vascular / drug effects,  metabolism
Heart Failure / physiopathology*
Norepinephrine / pharmacology
Phenylephrine / pharmacology
Vasodilation / drug effects*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Azepines; 36085-73-1/talipexole; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 59-42-7/Phenylephrine

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