| Endothelium-dependent relaxant effect of thrombin on isolated pig coronary arteries. | |
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MedLine Citation:
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PMID: 3248118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In pig coronary arteries with intact endothelium the clotting enzyme thrombin at physiologically relevant concentrations caused a reversible transient and concentration-dependent relaxation of PGF2 alpha-precontracted vessels which was absent in case of mechanically removed endothelium. The thrombin-induced relaxation was not affected by indomethacin. Exposure of the coronary arteries to a calcium-free medium or preincubation with verapamil led to the reduction of the PGF2 alpha-induced contraction while the relaxant effect of thrombin was only slightly inhibited. However, the guanylate cyclase inhibitor methylene blue diminished the relaxant response to thrombin. The specific tight-binding thrombin inhibitor hirudin prevented the relaxant effect of thrombin in a concentration-dependent manner. |
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Authors:
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E Glusa |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Biomedica biochimica acta Volume: 47 ISSN: 0232-766X ISO Abbreviation: Biomed. Biochim. Acta Publication Date: 1988 |
Date Detail:
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Created Date: 1989-06-15 Completed Date: 1989-06-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8304435 Medline TA: Biomed Biochim Acta Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: S67-70 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology and Toxicology, Medical Academy Erfurt, G.D.R. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bradykinin / pharmacology Coronary Vessels / drug effects, physiology* Dinoprost / pharmacology Endothelium, Vascular / physiology* Muscle, Smooth, Vascular / drug effects, physiology* Swine Thrombin / physiology* Vasoconstriction / drug effects Vasodilation* / drug effects |
| Chemical | |
Reg. No./Substance:
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551-11-1/Dinoprost; 58-82-2/Bradykinin; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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