Document Detail

Endothelins inhibit mineralization of rat calvarial osteoblast-like cells.
MedLine Citation:
PMID:  9595531     Owner:  NLM     Status:  MEDLINE    
We examined the effects of members of the endothelin (ET) family on mineralization of rat calvarial osteoblast-like cells. The accumulation of calcium in cells and cell layers was attenuated by ETs with the rank order of potency ET-1 = ET-2 > ET-3. We stained the mineralized nodules by von Kossa staining and measured the number and area of mineralized nodules. The inhibitory effects of ET-1 and ET-2 on the formation of mineralized nodules were stronger than those of ET-3. Our data suggest that ET-1 may inhibit the mineralization process of osteoblastic cells through the ETA receptor.
Y Hiruma; A Inoue; A Shiohama; E Otsuka; S Hirose; A Yamaguchi; H Hagiwara
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  31 Suppl 1     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-07-17     Completed Date:  1998-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S521-3     Citation Subset:  IM; S    
Research Center for Experimental Biology, Tokyo Institute of Technology, Yokohama, Japan.
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MeSH Terms
Animals, Newborn
Calcification, Physiologic / drug effects*
Calcium / metabolism
Cells, Cultured
Endothelins / pharmacology*
Osteoblasts / drug effects*,  metabolism
Rats, Wistar
Receptor, Endothelin A
Receptors, Endothelin / antagonists & inhibitors
Skull / cytology,  drug effects*
Reg. No./Substance:
0/Endothelins; 0/Receptor, Endothelin A; 0/Receptors, Endothelin; 7440-70-2/Calcium

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