Document Detail


Endothelin type A receptor antagonist attenuates placental ischemia-induced hypertension and uterine vascular resistance.
MedLine Citation:
PMID:  21458623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We sought to determine the effect of an endothelin type A receptor antagonist (ETA) on uterine artery resistive index (UARI) and mean arterial pressure (MAP) in a placental ischemia rat model of preeclampsia produced by reduction in uterine perfusion pressure (RUPP).
STUDY DESIGN: UARI was assessed by Doppler velocimetry in RUPP and normal pregnant controls (NP) on gestational days (GD) 12, 15, and 18. UARI was also determined on GD 18 in NP and RUPP pregnant dams after pretreatment with ETA. MAP was recorded on GD 19.
RESULTS: The RUPP group had a higher MAP and UARI on GD 15 and 18 than the NP group. Pretreatment with ETA attenuated both the MAP and GD-18 UARI in the RUPP group without affecting these parameters in the NP group.
CONCLUSION: The improvement in UARI could be one potential mechanism for the reduction in MAP in response to ETA in pregnant dams with ischemic placentas.
Authors:
Kiran B Tam Tam; Eric George; Kathy Cockrell; Marietta Arany; Joshua Speed; James N Martin; Babbette Lamarca; Joey P Granger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-06-28     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  330.e1-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Affiliation:
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity / drug effects,  physiology
Blood Pressure / drug effects,  physiology
Disease Models, Animal
Female
Hypertension / drug therapy*,  physiopathology
Ischemia / drug therapy,  physiopathology
Placenta / blood supply*,  drug effects,  physiopathology
Pregnancy
Pyrrolidines / pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Endothelin / antagonists & inhibitors*
Uterine Artery / physiopathology*,  ultrasonography
Vascular Resistance / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
HL-51971/HL/NHLBI NIH HHS; P01 HL051971-16/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/A 127722; 0/Pyrrolidines; 0/Receptors, Endothelin
Comments/Corrections

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