| Endothelin receptor subtype A blockade does not affect the haemodynamic recovery from haemorrhage during xenon/remifentanil or isoflurane/remifentanil anaesthesia in dogs. | |
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MedLine Citation:
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PMID: 20230551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To test the compensatory role of endothelin-1 when acute blood loss is superimposed on anaesthesia, by characterizing the effect of systemic endothelin receptor subtype A (ET(A)) blockade on the haemodynamic and hormonal responses to haemorrhage in dogs anaesthetized with xenon/remifentanil (X/R) or isoflurane/remifentanil (I/R). STUDY DESIGN: Prospective experimental randomized controlled study. ANIMALS: Six female Beagle dogs, 13.4 +/- 1.3 kg. METHODS: Animals were anaesthetized with remifentanil 0.5 microg kg(-1) minute(-1) plus either 0.8% isoflurane (I/R) or 63% xenon (X/R), with and without (Control) the systemic intravenous endothelin receptor subtype A antagonist atrasentan (four groups, n = 6 each). After 60 minutes of baseline anaesthesia, the dogs were bled (20 mL kg(-1)) over 5 minutes and hypovolemia was maintained for 1 hour. Continuous haemodynamic monitoring was performed via femoral and pulmonary artery catheters; vasoactive hormones were measured before and after haemorrhage. RESULTS: In Controls, systemic vascular resistance (SVR), vasopressin and catecholamine plasma concentrations were higher with X/R than with I/R anaesthesia at pre-haemorrhage baseline. The peak increase after haemorrhage was higher during X/R than during I/R anaesthesia (SVR 7420 +/- 867 versus 5423 +/- 547 dyne seconds cm(-5); vasopressin 104 +/- 23 versus 44 +/- 6 pg mL(-1); epinephrine 2956 +/- 310 versus 177 +/- 99 pg mL(-1); norepinephrine 862 +/- 117 versus 195 +/- 33 pg mL(-1), p < 0.05). Haemorrhage reduced central venous pressure from 3 +/- 1 to 1 +/- 1 cm H(2)O (I/R, ns) and from 8 +/- 1 to 5 +/- 1 cm H(2)O (X/R, p < 0.05), but did not reduce mean arterial pressure, nor cardiac output. Atrasentan did not alter the haemodynamic and hormonal response to haemorrhage during either anaesthetic protocol. CONCLUSIONS AND CLINICAL RELEVANCE: Selective ET(A) receptor blockade with atrasentan did not impair the haemodynamic and hormonal compensation of acute haemorrhage during X/R or I/R anaesthesia in dogs. |
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Authors:
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Roland C E Francis; Claudia Höhne; Adrian Klein; Udo X Kaisers; Philipp A Pickerodt; Willehad Boemke |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-11 |
Journal Detail:
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Title: Veterinary anaesthesia and analgesia Volume: 37 ISSN: 1467-2995 ISO Abbreviation: Vet Anaesth Analg Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-11 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100956422 Medline TA: Vet Anaesth Analg Country: England |
Other Details:
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Languages: eng Pagination: 258-68 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany. roland.francis@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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methods,
veterinary* Anesthesia, Inhalation / methods, veterinary Anesthesia, Intravenous / methods, veterinary Anesthetics, Inhalation* Anesthetics, Intravenous* Animals Blood Loss, Surgical / physiopathology, veterinary Catecholamines / blood Dog Diseases / physiopathology* Dogs Endothelin-1 / blood Epinephrine / blood Female Hemodynamics / drug effects* Hemorrhage / physiopathology, veterinary* Isoflurane* Norepinephrine / blood Piperidines* Pyrrolidines / pharmacology* Receptor, Endothelin A / antagonists & inhibitors* Time Factors Vascular Resistance / drug effects Vasopressins / blood Xenon* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Catecholamines; 0/Endothelin-1; 0/Piperidines; 0/Pyrrolidines; 0/Receptor, Endothelin A; 0/atrasentan; 11000-17-2/Vasopressins; 132875-61-7/remifentanil; 26675-46-7/Isoflurane; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7440-63-3/Xenon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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