Document Detail

Endothelin receptor A blockade alters hemodynamic response to nitric oxide inhibition in rats.
MedLine Citation:
PMID:  7653640     Owner:  NLM     Status:  MEDLINE    
We examined the extent to which the systemic and renal vasoconstriction induced by nitric oxide (NO) inhibition in vivo is mediated by endothelin (ET). We examined the effects of BQ-610, a specific ETA-receptor antagonist, after NO inhibition with N omega-nitro-L-arginine methyl ester (L-NAME) in the anesthetized rat. Mean arterial pressure (MAP) increased after L-NAME infusion from 107 +/- 2 to 133 +/- 3 mmHg (P < 0.05 vs. baseline period) then fell to 115 +/- 3 mmHg after administration of BQ-610 (P < 0.05 vs. L-NAME and baseline periods). Systemic vascular resistance (SVR) increased from 1.26 +/- 0.06 to 2.17 +/- 0.18 g after L-NAME (P < 0.05 vs. baseline period) then fell to 1.69 +/- 0.12 g after BQ-610 (P < 0.05 vs. L-NAME and baseline periods). The increase in renal vascular resistance (RVR) from 6.4 +/- 0.4 to 13.7 +/- 1.4 g induced by L-NAME (P < 0.05 vs. baseline period) was reduced to 11.1 +/- 1.0 g by BQ-610 (P < 0.05 vs. L-NAME and baseline periods). The extent to which BQ-610 reversed the L-NAME-induced increases in RVR and SVR was comparable (RVR by 40 +/- 9%; SVR by 52 +/- 7%). Glomerular filtration rate and renal blood flow were both reduced by L-NAME, but neither value increased after BQ-610, possibly because the renal vasodilation induced by ETA blockade was offset by the concomitant reduction in MAP and renal perfusion pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
A Thompson; C R Valeri; W Lieberthal
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  269     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-22     Completed Date:  1995-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H743-8     Citation Subset:  IM    
Evans Memorial Department of Clinical Research, Boston University Medical Center, Massachusetts 02118, USA.
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MeSH Terms
Arginine / analogs & derivatives,  pharmacology
Blood Pressure / drug effects
Hemodynamics* / drug effects
NG-Nitroarginine Methyl Ester
Nitric Oxide / antagonists & inhibitors*
Oligopeptides / pharmacology
Rats, Sprague-Dawley
Receptors, Endothelin / antagonists & inhibitors*
Renal Circulation / drug effects
Grant Support
Reg. No./Substance:
0/Oligopeptides; 0/Receptors, Endothelin; 10102-43-9/Nitric Oxide; 141595-53-1/BQ 610; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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