Document Detail


Endothelin receptor A blockade alters hemodynamic response to nitric oxide inhibition in rats.
MedLine Citation:
PMID:  7653640     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the extent to which the systemic and renal vasoconstriction induced by nitric oxide (NO) inhibition in vivo is mediated by endothelin (ET). We examined the effects of BQ-610, a specific ETA-receptor antagonist, after NO inhibition with N omega-nitro-L-arginine methyl ester (L-NAME) in the anesthetized rat. Mean arterial pressure (MAP) increased after L-NAME infusion from 107 +/- 2 to 133 +/- 3 mmHg (P < 0.05 vs. baseline period) then fell to 115 +/- 3 mmHg after administration of BQ-610 (P < 0.05 vs. L-NAME and baseline periods). Systemic vascular resistance (SVR) increased from 1.26 +/- 0.06 to 2.17 +/- 0.18 mmHg.ml-1.min.300 g after L-NAME (P < 0.05 vs. baseline period) then fell to 1.69 +/- 0.12 mmHg.ml-1.min.300 g after BQ-610 (P < 0.05 vs. L-NAME and baseline periods). The increase in renal vascular resistance (RVR) from 6.4 +/- 0.4 to 13.7 +/- 1.4 mmHg.ml-1.min.300 g induced by L-NAME (P < 0.05 vs. baseline period) was reduced to 11.1 +/- 1.0 mmHg.ml-1.min.300 g by BQ-610 (P < 0.05 vs. L-NAME and baseline periods). The extent to which BQ-610 reversed the L-NAME-induced increases in RVR and SVR was comparable (RVR by 40 +/- 9%; SVR by 52 +/- 7%). Glomerular filtration rate and renal blood flow were both reduced by L-NAME, but neither value increased after BQ-610, possibly because the renal vasodilation induced by ETA blockade was offset by the concomitant reduction in MAP and renal perfusion pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
A Thompson; C R Valeri; W Lieberthal
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  269     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-22     Completed Date:  1995-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H743-8     Citation Subset:  IM    
Affiliation:
Evans Memorial Department of Clinical Research, Boston University Medical Center, Massachusetts 02118, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine / analogs & derivatives,  pharmacology
Blood Pressure / drug effects
Hemodynamics* / drug effects
Male
NG-Nitroarginine Methyl Ester
Nitric Oxide / antagonists & inhibitors*
Oligopeptides / pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Endothelin / antagonists & inhibitors*
Renal Circulation / drug effects
Grant Support
ID/Acronym/Agency:
DK-37105/DK/NIDDK NIH HHS; HL-53031/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Oligopeptides; 0/Receptors, Endothelin; 10102-43-9/Nitric Oxide; 141595-53-1/BQ 610; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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