| Endothelin receptor A blockade alters hemodynamic response to nitric oxide inhibition in rats. | |
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MedLine Citation:
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PMID: 7653640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the extent to which the systemic and renal vasoconstriction induced by nitric oxide (NO) inhibition in vivo is mediated by endothelin (ET). We examined the effects of BQ-610, a specific ETA-receptor antagonist, after NO inhibition with N omega-nitro-L-arginine methyl ester (L-NAME) in the anesthetized rat. Mean arterial pressure (MAP) increased after L-NAME infusion from 107 +/- 2 to 133 +/- 3 mmHg (P < 0.05 vs. baseline period) then fell to 115 +/- 3 mmHg after administration of BQ-610 (P < 0.05 vs. L-NAME and baseline periods). Systemic vascular resistance (SVR) increased from 1.26 +/- 0.06 to 2.17 +/- 0.18 mmHg.ml-1.min.300 g after L-NAME (P < 0.05 vs. baseline period) then fell to 1.69 +/- 0.12 mmHg.ml-1.min.300 g after BQ-610 (P < 0.05 vs. L-NAME and baseline periods). The increase in renal vascular resistance (RVR) from 6.4 +/- 0.4 to 13.7 +/- 1.4 mmHg.ml-1.min.300 g induced by L-NAME (P < 0.05 vs. baseline period) was reduced to 11.1 +/- 1.0 mmHg.ml-1.min.300 g by BQ-610 (P < 0.05 vs. L-NAME and baseline periods). The extent to which BQ-610 reversed the L-NAME-induced increases in RVR and SVR was comparable (RVR by 40 +/- 9%; SVR by 52 +/- 7%). Glomerular filtration rate and renal blood flow were both reduced by L-NAME, but neither value increased after BQ-610, possibly because the renal vasodilation induced by ETA blockade was offset by the concomitant reduction in MAP and renal perfusion pressure.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A Thompson; C R Valeri; W Lieberthal |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 269 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-22 Completed Date: 1995-09-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H743-8 Citation Subset: IM |
Affiliation:
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Evans Memorial Department of Clinical Research, Boston University Medical Center, Massachusetts 02118, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / analogs & derivatives, pharmacology Blood Pressure / drug effects Hemodynamics* / drug effects Male NG-Nitroarginine Methyl Ester Nitric Oxide / antagonists & inhibitors* Oligopeptides / pharmacology Rats Rats, Sprague-Dawley Receptors, Endothelin / antagonists & inhibitors* Renal Circulation / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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DK-37105/DK/NIDDK NIH HHS; HL-53031/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Oligopeptides; 0/Receptors, Endothelin; 10102-43-9/Nitric Oxide; 141595-53-1/BQ 610; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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