| Endothelin receptor antagonists in the treatment of pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 17338931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The recognition that endothelin-1 contributes to the pathogenesis of pulmonary arterial hypertension has led to the development of clinically useful endothelin receptor antagonists that improve symptoms and functional capacity and alter the natural history of the disease in a beneficial way. The antagonists have varying degrees of selectivity for the two classes of endothelin receptor, termed ETA and ETB, and the varying degrees may translate into clinical differences. Endothelin receptor antagonists have become an integral part of therapy for pulmonary arterial hypertension, and the indications for their use are expanding. |
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Authors:
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David Langleben |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinics in chest medicine Volume: 28 ISSN: 0272-5231 ISO Abbreviation: Clin. Chest Med. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-06 Completed Date: 2007-05-15 Revised Date: 2008-06-05 |
Medline Journal Info:
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Nlm Unique ID: 7907612 Medline TA: Clin Chest Med Country: United States |
Other Details:
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Languages: eng Pagination: 117-25, viii Citation Subset: IM |
Affiliation:
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McGill University, Montreal, Quebec, Canada. david.langleben@mcgill.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use Drug Therapy, Combination Humans Hypertension, Pulmonary / drug therapy* Isoxazoles / therapeutic use Phenylpropionates / therapeutic use Pyridazines / therapeutic use Randomized Controlled Trials as Topic Receptors, Endothelin / antagonists & inhibitors* Sulfonamides / therapeutic use Thiophenes / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Isoxazoles; 0/Phenylpropionates; 0/Pyridazines; 0/Receptors, Endothelin; 0/Sulfonamides; 0/Thiophenes; 0/sitaxsentan; 147536-97-8/bosentan; 177036-94-1/ambrisentan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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