Document Detail

Endothelin production by amnion and its regulation by cytokines.
MedLine Citation:
PMID:  1853887     Owner:  NLM     Status:  MEDLINE    
Cells derived from human amnion, an avascular tissue, produced significant amounts of endothelin 1 and 2, although the rate of biosynthesis was approximately one tenth of that of human umbilical vein endothelial cells. Endothelin 1 and 2 was not produced in measurable amounts by cells derived from chorion laeve or decidua. Production of endothelin 1 and 2 by amnion cells was increased by treatment with the cytokines interleukin-1 beta, tumor necrosis factor, and interleukin-6. The biosynthesis of endothelin 1 and 2 by an avascular tissue is suggestive of a wider role for endothelins than has been recognized.
M D Mitchell; S Lundin-Schiller; S S Edwin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  165     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-21     Completed Date:  1991-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  120-4     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Utah, Salt Lake City.
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MeSH Terms
Amnion / cytology,  metabolism*
Cells, Cultured
Culture Media
Cytokines / pharmacology*
Endothelins / biosynthesis*
Interleukin-1 / pharmacology
Interleukin-6 / pharmacology
Lymphotoxin-alpha / pharmacology
Grant Support
Reg. No./Substance:
0/Culture Media; 0/Cytokines; 0/Endothelins; 0/Interleukin-1; 0/Interleukin-6; 0/Lymphotoxin-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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