| Endothelin and the neurovascular unit in pediatric traumatic brain injury. | |
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MedLine Citation:
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PMID: 21801587 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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METHODS: Lateral fluid percussion injury was induced in newborn pigs equipped with a closed cranial window. Cerebral blood flow was determined with radiolabeled microspheres and cerebrospinal fluid endothelin-1 was measured by radioimmunoassay. RESULTS: Cerebrospinal fluid endothelin-1 was increased from 26±4 to 296±37 pg/ml (∼10(-10)M) at 8 hours following fluid percussion injury. Post-injury treatment (30 minutes) with the endothelin-1 antagonist BQ-123 (1 mg/kg, intravenous) blocked pial artery vasoconstriction to topical endothelin-1 (∼10(-10)M) and blunted fluid percussion injury-induced reductions in cerebral blood flow at 8 hours post-insult (56±6 and 26±4ml/minute versus 57±6 and 40± ml/minute; 100 g for cerebral blood flow before injury and 8 hours post-fluid percussion injury in vehicle and BQ-123 post-treated animals, respectively). Fluid percussion injury resulted in neuronal cell loss and decreased microtubule associated protein 2 immunoreactivity in the parietal cortex, which were blunted by BQ-123. DISCUSSION: These data indicate that fluid percussion injury-induced changes in cerebral hemodynamics are associated with neuronal damage and that endothelin-1 contributes to fluid percussion injury-induced histopathologic changes. |
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Authors:
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William M Armstead; Ramesh Raghupathi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurological research Volume: 33 ISSN: 1743-1328 ISO Abbreviation: Neurol. Res. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-08-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
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Languages: eng Pagination: 127-32 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Critical Care and Department of Pharmacology, University of Pennsylvania, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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