| Endothelin: a mediator of renal disease progression. | |
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MedLine Citation:
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PMID: 9377723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glomerulosclerosis and tubulointerstitial damage are characteristics of progressive renal diseases associated with chronic proteinuria. Since numerous studies have demonstrated a correlation between proteinuria and the degree of renal damage, a causal role for proteinuria in the development of progressive renal failure has been postulated. Some in vitro data suggest that endothelins (ET), a family of endogenous peptides, could be involved in the genesis and progression of glomerular damage. Moreover, evidence that tubular cells exposed to high molecular weight proteins are induced to release ET toward the basolateral compartment, together with the capability of these peptides to influence events occurring in the interstitium, suggest that ET could also participate in interstitial inflammation. Data are now available that ET actually plays a role in the progression of chronic renal disease in different experimental models including renal mass reduction, lupus nephritis and streptozotocin-induced diabetes. |
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Authors:
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I Bruzzi; G Remuzzi; A Benigni |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of nephrology Volume: 10 ISSN: 1121-8428 ISO Abbreviation: J. Nephrol. Publication Date: 1997 Jul-Aug |
Date Detail:
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Created Date: 1997-11-07 Completed Date: 1997-11-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9012268 Medline TA: J Nephrol Country: ITALY |
Other Details:
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Languages: eng Pagination: 179-83 Citation Subset: IM |
Affiliation:
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Mario Negri Institute for Pharmacological Research, Bergamo, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Experimental / drug therapy Disease Progression Endothelin-1 / metabolism, pharmacology, physiology* Endothelins / metabolism, physiology Kidney Diseases / etiology*, physiopathology Lupus Vulgaris / drug therapy Rats Receptors, Endothelin / chemistry Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Endothelin-1; 0/Endothelins; 0/Receptors, Endothelin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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