| Endothelin levels in Henoch-Schonlein purpura. | |
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MedLine Citation:
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PMID: 12432435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Henoch-Schonlein purpura (HSP) is one of the most common types of vasculitis disorders seen in childhood and is characterized by a rash, arthritis, abdominal pain, and renal involvement. Although HSP is an immunoglobulin A (IgA) related immune complex disease, the pathogenesis has not been fully elucidated. Cytokines have been implicated in the pathogenesis, but endothelins (ET) - vasoconstrictor hormones produced by endothelial cells - have not been studied in patients with HSP. In a controlled study, we measured ET-1 levels in children with HSP during the acute and remission phases. ET-1 levels were significantly higher in the HSP patients during the acute phase compared with the control group and the HSP patients in the remission phase. There was no correlation between ET-1 levels and disease severity, acute phase reactant response, or morbidity. The role of endothelins and other cytokines in the pathogenesis of HSP needs to be further explored. |
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Authors:
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Ali Muslu; Ismail Islek; Faysal Gok; Yuksel Aliyazicioglu; Ayhan Dagdemir; Rusen Dundaroz; Sukru Kucukoduk; Abdullah Sakarcan |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2002-09-25 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 17 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-14 Completed Date: 2003-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 920-5 Citation Subset: IM |
Affiliation:
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Ondokuz Mayis University, School of Medicine, Department of Pediatrics, 55139 Samsun, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Arthritis / etiology Blood Cell Count Child Child, Preschool Cytokines / blood Endothelins / blood* Female Hematuria / etiology Hemoglobins / metabolism Humans Infant Kidney Function Tests Male Purpura, Schoenlein-Henoch / blood*, complications, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Endothelins; 0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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