Document Detail


Endothelin levels in Henoch-Schonlein purpura.
MedLine Citation:
PMID:  12432435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Henoch-Schonlein purpura (HSP) is one of the most common types of vasculitis disorders seen in childhood and is characterized by a rash, arthritis, abdominal pain, and renal involvement. Although HSP is an immunoglobulin A (IgA) related immune complex disease, the pathogenesis has not been fully elucidated. Cytokines have been implicated in the pathogenesis, but endothelins (ET) - vasoconstrictor hormones produced by endothelial cells - have not been studied in patients with HSP. In a controlled study, we measured ET-1 levels in children with HSP during the acute and remission phases. ET-1 levels were significantly higher in the HSP patients during the acute phase compared with the control group and the HSP patients in the remission phase. There was no correlation between ET-1 levels and disease severity, acute phase reactant response, or morbidity. The role of endothelins and other cytokines in the pathogenesis of HSP needs to be further explored.
Authors:
Ali Muslu; Ismail Islek; Faysal Gok; Yuksel Aliyazicioglu; Ayhan Dagdemir; Rusen Dundaroz; Sukru Kucukoduk; Abdullah Sakarcan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-09-25
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  17     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-14     Completed Date:  2003-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  920-5     Citation Subset:  IM    
Affiliation:
Ondokuz Mayis University, School of Medicine, Department of Pediatrics, 55139 Samsun, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Arthritis / etiology
Blood Cell Count
Child
Child, Preschool
Cytokines / blood
Endothelins / blood*
Female
Hematuria / etiology
Hemoglobins / metabolism
Humans
Infant
Kidney Function Tests
Male
Purpura, Schoenlein-Henoch / blood*,  complications,  physiopathology
Chemical
Reg. No./Substance:
0/Cytokines; 0/Endothelins; 0/Hemoglobins

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