| Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers. | |
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MedLine Citation:
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PMID: 9618495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A regular heart beat is dependent on a specialized network of pacemaking and conductive cells. There has been a longstanding controversy regarding the developmental origin of these cardiac tissues which also manifest neural-like properties. Recently, we have shown conclusively that during chicken embryogenesis, impulse-conducting Purkinje cells are recruited from myocytes in spatial association with developing coronary arteries. Here, we report that cultured embryonic myocytes convert to a Purkinje cell phenotype after exposure to the vascular cytokine, endothelin. This inductive response declined gradually during development. These results yield further evidence for a role of arteriogenesis in the induction of impulse-conducting Purkinje cells within the heart muscle lineage and also may provide a basis for tissue engineering of cardiac pacemaking and conductive cells. |
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Authors:
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R G Gourdie; Y Wei; D Kim; S C Klatt; T Mikawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 95 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-07-09 Completed Date: 1998-07-09 Revised Date: 2013-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6815-8 Citation Subset: IM |
Affiliation:
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Department of Cell Biology and Anatomy, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / drug effects, physiology Cells, Cultured Chick Embryo Endothelins / pharmacology*, physiology Heart / embryology*, physiology Myocardial Contraction Myocardium / cytology* Purkinje Fibers / cytology*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Endothelins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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