Document Detail

Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers.
MedLine Citation:
PMID:  9618495     Owner:  NLM     Status:  MEDLINE    
A regular heart beat is dependent on a specialized network of pacemaking and conductive cells. There has been a longstanding controversy regarding the developmental origin of these cardiac tissues which also manifest neural-like properties. Recently, we have shown conclusively that during chicken embryogenesis, impulse-conducting Purkinje cells are recruited from myocytes in spatial association with developing coronary arteries. Here, we report that cultured embryonic myocytes convert to a Purkinje cell phenotype after exposure to the vascular cytokine, endothelin. This inductive response declined gradually during development. These results yield further evidence for a role of arteriogenesis in the induction of impulse-conducting Purkinje cells within the heart muscle lineage and also may provide a basis for tissue engineering of cardiac pacemaking and conductive cells.
R G Gourdie; Y Wei; D Kim; S C Klatt; T Mikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  95     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-09     Completed Date:  1998-07-09     Revised Date:  2013-04-17    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  6815-8     Citation Subset:  IM    
Department of Cell Biology and Anatomy, Cornell University Medical College, 1300 York Avenue, New York, NY 10021, USA.
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MeSH Terms
Cell Differentiation / drug effects,  physiology
Cells, Cultured
Chick Embryo
Endothelins / pharmacology*,  physiology
Heart / embryology*,  physiology
Myocardial Contraction
Myocardium / cytology*
Purkinje Fibers / cytology*,  physiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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