Document Detail

Endothelin contributes to the hemodynamic effects of vasopressin in spontaneous hypertension.
MedLine Citation:
PMID:  9346328     Owner:  NLM     Status:  MEDLINE    
Changes in blood pressure, cardiac output, and total peripheral conductance evoked by intravenous infusions of [Arg8]-vasopressin (vasopressin) were recorded before and after pretreatment with bosentan, a non-selective endothelin antagonist, in conscious unrestrained spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). The presser effects of vasopressin were exaggerated in SHR compared to WKY. Pretreatment with bosentan failed to change hemodynamic responses of WKY to vasopressin, but it blunted the increases in blood pressure and the decreases in conductance evoked by vasopressin in SHR. In contrast, bosentan failed to change cardiac output responses of SHR to vasopressin. Except at the highest dose of vasopressin, bosentan abolished the exaggerated pressor responsiveness of the SHR to vasopressin. The results suggest that endothelin contributes to the exaggerated pressor responsiveness of SHR to vasopressin, and that this effect is exerted at the level of the resistance vessels and not on factors that regulate cardiac output.
S M Balakrishnan; V Gopalakrishnan; J R McNeill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  334     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-02-05     Completed Date:  1998-02-05     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects
Cardiac Output / drug effects
Dose-Response Relationship, Drug
Endothelin-1 / physiology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy*
Rats, Inbred SHR
Rats, Inbred WKY
Sulfonamides / pharmacology*
Vasoconstrictor Agents / administration & dosage,  pharmacology*
Vasopressins / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelin-1; 0/Sulfonamides; 0/Vasoconstrictor Agents; 11000-17-2/Vasopressins; Q326023R30/bosentan

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