Document Detail


Endothelin contributes to the hemodynamic effects of vasopressin in spontaneous hypertension.
MedLine Citation:
PMID:  9346328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Changes in blood pressure, cardiac output, and total peripheral conductance evoked by intravenous infusions of [Arg8]-vasopressin (vasopressin) were recorded before and after pretreatment with bosentan, a non-selective endothelin antagonist, in conscious unrestrained spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). The presser effects of vasopressin were exaggerated in SHR compared to WKY. Pretreatment with bosentan failed to change hemodynamic responses of WKY to vasopressin, but it blunted the increases in blood pressure and the decreases in conductance evoked by vasopressin in SHR. In contrast, bosentan failed to change cardiac output responses of SHR to vasopressin. Except at the highest dose of vasopressin, bosentan abolished the exaggerated pressor responsiveness of the SHR to vasopressin. The results suggest that endothelin contributes to the exaggerated pressor responsiveness of SHR to vasopressin, and that this effect is exerted at the level of the resistance vessels and not on factors that regulate cardiac output.
Authors:
S M Balakrishnan; V Gopalakrishnan; J R McNeill
Related Documents :
20865358 - Perinatal l-arginine and antioxidant supplements reduce adult blood pressure but not am...
2944768 - Rapid transient analysis of myosin cross-bridge kinetics in hypertrophied hearts.
14621188 - Central cardiovascular action of urotensin ii in spontaneously hypertensive rats.
8750968 - Hypertensive effect of tissue kallikrein in rostral ventrolateral medulla is mediated b...
19873318 - Hydrostatic pressure and temperature in relation to stimulation and cyclosis in nitella...
2676558 - Effects of low-dose atenolol on postural and postprandial changes in heart rate, blood ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  334     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-02-05     Completed Date:  1998-02-05     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects
Cardiac Output / drug effects
Dose-Response Relationship, Drug
Endothelin-1 / physiology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Sulfonamides / pharmacology*
Vasoconstrictor Agents / administration & dosage,  pharmacology*
Vasopressins / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelin-1; 0/Sulfonamides; 0/Vasoconstrictor Agents; 11000-17-2/Vasopressins; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Contribution of endopeptidase 3.4.24.15 to central neurotensin inactivation.
Next Document:  Distinct receptors mediate pituitary adenylate cyclase-activating peptide- and vasoactive intestinal...