| Endothelin antagonists and heart failure. | |
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MedLine Citation:
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PMID: 11790297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic heart failure (CHF) is characterized by impaired left ventricular function, increased peripheral and pulmonary vascular resistance, reduced exercise tolerance, and dyspnea. Despite considerable progress in the treatment of CHF, especially in targeting activated neurohumoral systems, mortality in these patients remains high. Therefore, new treatment approaches are warranted. Endothelin-1 (ET-1) plasma levels are elevated in CHF and correlate with both hemodynamic severity and symptoms. Plasma levels of ET-1 are strong independent predictors of mortality in CHF. Combined ET(A/B) selective ET(A) receptor antagonists have been evaluated in patients with CHF showing impressive hemodynamic improvements. These results indicate that ET receptor antagonists indeed have a potential to improve hemodynamics, symptoms, and potentially prognosis in patients with CHF, which still carries a high mortality. |
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Authors:
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David Hürlimann; Frank Enseleit; Georg Noll; Thomas F Lüscher; Frank Ruschitzka |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 4 ISSN: 1522-6417 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-15 Completed Date: 2002-04-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 85-92 Citation Subset: IM |
Affiliation:
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Cardio Vascular Center, Cardiology, University Hospital, CH - 8091 Zürich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Endothelins
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antagonists & inhibitors,
physiology* Heart Failure / drug therapy, physiopathology* Hemodynamics / drug effects Humans Hypertension / drug therapy, physiopathology* Pyrrolidines / therapeutic use Receptors, Endothelin / antagonists & inhibitors*, physiology Sulfonamides / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/A 127722; 0/Endothelins; 0/Pyrrolidines; 0/Receptors, Endothelin; 0/Sulfonamides; 147536-97-8/bosentan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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