| Endothelin receptor antagonists for pulmonary arterial hypertension: an overview. | |
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MedLine Citation:
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PMID: 20406243 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The last decade has seen major advances in the pharmacotherapy of pulmonary arterial hypertension (PAH). One of these advances has been the discovery of endothelin receptor antagonists (ERAs). ERAs are a class of potent vasodilators and antimitotic substances, which could specifically dilate and remodel pulmonary arterial system, and have been proposed as an alternative to traditional therapies for PAH. Current available evidence suggests that ERAs improve exercise capacity, functional status, pulmonary hemodynamics, and delay the time to clinical worsening for patients with PAH. This review attempts to provide an overview of the pharmacology, therapeutic benefits, and safety profile of ERAs in patients with PAH. |
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Authors:
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Shahzad G Raja |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular therapeutics Volume: 28 ISSN: 1755-5922 ISO Abbreviation: Cardiovasc Ther Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101319630 Medline TA: Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: e65-71 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Department of Cardiothoracic Surgery, Great Ormond Street Hospital, London, UK. drrajashahzad@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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