| Endothelin: Key Mediator of Hypertension in Preeclampsia. | |
| | |
MedLine Citation:
|
PMID: 21677700 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Preeclampsia is a pregnancy-induced hypertensive disorder characterized by proteinuria and widespread maternal endothelial dysfunction. It remains one of the most common disorders in pregnancy and remains one of the leading causes of maternal and fetal morbidity. Recent research has revealed that placental insufficiency, resulting in hypoxia and ischemia, is a central causative pathway in the development of the disorder. In response, the placenta secretes soluble substances into the maternal circulation which are responsible for the symptomatic phase of the disease. Among the most well characterized factors in the disease pathology are the anti-angiogenic protein soluble fms-like tyrosine kinase-1 (sFlt-1), inflammatory cytokines, and agonistic angiotensin II type-1 receptor autoantibodies. Each of these factors has been shown to induce hypertension experimentally through the production of endothelin-1 (ET-1), a powerful vasoconstrictor. Antagonism of the endothelin-A receptor has proved beneficial in numerous animal models of gestational hypertension, and it remains an intriguing target for pharmacological intervention in preeclampsia.American Journal of Hypertension (2011). doi:10.1038/ajh.2011.99. |
| | |
Authors:
|
Eric M George; Joey P Granger |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-16 |
Journal Detail:
|
Title: American journal of hypertension Volume: - ISSN: 1879-1905 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differences in Blood Pressure by Body Position (Supine, Fowler's, and Sitting) in Hypertensive Subje...
Next Document: Endothelial-Dependent Flow-Mediated Dilation in African Americans With Masked-Hypertension.